II. Dosing: Deep Sedation in Adults
- Weight-based adjustment
- Weight over 90 kg: Dose at 90 kg
- Weight under 60 kg: Dose at 60 kg
- Age under 65 years old
- Starting dose: 6.5 mg/kg (up to 16.5 ml max)
- Supplemental dose: 1.6 mg/kg IV every 4 minutes (up to 4 ml max)
- Age 65 years and older (or severe systemic disease)
- Dose at 75% of that listed above
III. Mechanism
- Activity is same as Propofol once metabolized
- Prodrug for Propofol
- Metabolized to Propofol by Alkaline Phosphatase
- Equivalence to Propofol is 1 mmol to 1 mmol
-
Drug Abuse potential
- Schedule IV Drug
- Clear liquid that can be mixed with water
- Orally absorbed
- Onset of action is 4 minutes delayed beyond onset of Propofol (due to metabolism step)
- Reference
- Majoewsky (2012) EM:RAP 12(1): 3
IV. Adverse Effects
- Same as Propofol