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Definition (CHV)
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an immunosuppressive drug
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Definition (CHV)
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an immunosuppressive drug
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Definition (CHV)
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an immunosuppressive drug
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Definition (CHV)
|
an immunosuppressive drug
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Definition (NCI)
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A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
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Definition (MSH)
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An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
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Definition (CSP)
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immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D001379
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| SnomedCT |
391800005, 327060009, 317390007, 111165009, 372574004 |
| LNC |
LP18898-4, MTHU006794 |
| English |
Azathioprine, Azothioprine, 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, Azathioprine [gastrointestinal], Azathioprine [gi], Azathioprine [immunosuppress], 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, azathioprine, Azathioprine [immunosuppressant], AZTP, azathioprine (medication), AZATHIOPRINE, Azathioprine [Chemical/Ingredient], atps, ATP, azothioprine, azaTHIOprine, AzaTHIOprine, Azathioprine - chemical (substance), Azathioprine [immunosuppressant] (product), Azathioprine - chemical, Azathioprine [gastrointestinal] (product), AZT - Azathioprine, Azathioprine (product), Azathioprine (substance), Azathioprine [gastrointestinal] (substance), AZA |
| Swedish |
Azatioprin
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| Czech |
azathioprin
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| Finnish |
Atsatiopriini
|
| Italian |
Azotioprina, Azatioprina |
| Russian |
IMURAN, AZATIOPRIN, АЗАТИОПРИН, ИМУРАН |
| Japanese |
イムラン, アザチオプリン |
| Polish |
Azatiopryna
|
| Spanish |
azatioprina (gastrointestinal) (producto), azatioprina (gastrointestinal), azatioprina (producto), azatioprina (sustancia), azatioprina, Azatioprina |
| French |
Azathioprine
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| German |
Azathioprin
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| Portuguese |
Azatioprina
|
