II. Epidemiology

  1. Women account for 75% of Autoimmunity
  2. Age of onset is most common in young adult women

III. Mechanism

  1. Autoantibody, T-Cell mediated self tissue destruction
  2. Predisposing factors
    1. Autoimmunity increases with age: lower self tolerance
    2. Genetic predisposition
  3. Protective factors
    1. Autoimmunity less common where high antigen exposure
    2. Protective exposures in first year of life
      1. Eating dirt
      2. Living on a farm
      3. House pet
      4. Day care
    3. References
      1. Weiss (2002) N Engl J Med 347:930 [PubMed]

IV. Associated Conditions: Dermatologic Autoimmune Conditions

V. Associated Conditions: Endocrine Autoimmune Conditions

VI. Associated Conditions: Gastrointestinal Autoimmune Conditions

VII. Associated Conditions: Hematologic Autoimmune Conditions

IX. Associated Conditions: Neurologic Autoimmune Conditions

X. Associated Conditions: Vascular Autoimmune Conditions

XI. References

  1. Zuber (2003) AAFP Board Review, Seattle

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Ontology: Autoimmune Diseases (C0004364)

Definition (MEDLINEPLUS)

Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body.

No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases.

There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling.

The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

Definition (NCI_CTCAE) A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents.
Definition (NCI) A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).
Definition (NCI_NCI-GLOSS) A condition in which the body recognizes its own tissues as foreign and directs an immune response against them.
Definition (MSH) Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Definition (CSP) heading term for a diverse group of disorders characterized by pathologenic immune reactions to autologous (self) tissue; for nonnpatholgical, developmental, or phenomenological aspects of autoimmunity, use AUTOIMMUNITY.
Concepts Disease or Syndrome (T047)
MSH D001327
ICD10 M30-M36
SnomedCT 191006002, 85828009
LNC LP128504-0, LP130888-3, MTHU040269, MTHU040494
English Autoimmune Diseases, Disease, Autoimmune, Diseases, Autoimmune, autoimmune disorder, AUTOIMMUNE DISEASE, AUTOIMMUNE DISORDER NOS, AUTOIMMUNE DIS, autoimmune disease (diagnosis), autoimmune disease, Autoimmune disorder NOS, Autoimmune disorders, Autoimmune disease NOS, autoimmune disease NOS, Autoimmune Diseases [Disease/Finding], autoimmune diseases, autoimmune disorders, Autoimmune Disease, Autoimmune disease NOS (disorder), Autoimmune diseases, DISEASE, AUTOIMMUNE, Autoimmune disease, Autoimmune disorder, Autoimmune disease (disorder), Autoimmune disease, NOS, Autoimmune disorder, NOS, Autoimmune Disorders, Autoimmune Disorder
Italian Patologia autoimmune, Patologie autoimmuni, Patologia autoimmune NAS, Malattie autoimmuni
Dutch auto-immuunziekte NAO, auto-immuunziekten, auto-immuunziekte, Auto-immuunziekte, Auto-immuunziekten, Immuunziekte, auto-, Ziekte, auto-immuun-, Ziekten, auto-immuun-
French Troubles auto-immuns SAI, DESORDRES AUTO-IMMUNS SAI, Trouble auto-immun, Troubles auto-immuns, Maladies autoimmunes, Maladies auto-immunes
German Autoimmunerkrankung NNB, Autoimmunerkrankung, Autoimmunstoerungen, Autoimmunkrankheiten, Krankheiten, Autoimmun-
Portuguese Doença auto-imune NE, DOENCA AUTOIMUNE, Doenças Autoimunes, Afecções auto-imunes, Doença auto-imune
Spanish Trastorno autoinmune NEOM, enfermedad autoinmune, enfermedad autoinmunitaria, SAI (trastorno), enfermedad autoinmunológica, SAI, enfermedad autoinmunitaria, SAI, Trastornos autoinmunes, Trastorno autoinmune, enfermedad autoinmune (trastorno), enfermedad autoinmunológica, SAI (trastorno), trastorno autoinmune, enfermedad autoinmunitaria (trastorno), enfermedad autoinmunitaria, Enfermedades Autoinmunes
Japanese 自己免疫障害, 自己免疫障害NOS, ジコメンエキショウガイNOS, ジコメンエキショウガイ
Swedish Autoimmuna sjukdomar
Czech autoimunitní nemoci, Autoimunitní onemocnění NOS, Poruchy autoimunity, Autoimunitní onemocnění
Finnish Autoimmuunitaudit
Russian AUTOIMMUNNYE BOLEZNI, АУТОИММУННЫЕ БОЛЕЗНИ
Croatian AUTOIMUNOSNE BOLESTI
Polish Choroby autoimmunizacyjne, Choroby z autoagresji
Hungarian Autoimmun betegség, Autoimmun betegségek, Autoimmun betegség k.m.n.
Norwegian Autoimmune sykdommer, Autoimmun sykdom

Ontology: Autoimmunity (C0004368)

Definition (NCI) Autoimmune Status; the state of a person's health in regard to autoimmune disease or antibody presence.
Definition (MSH) Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Definition (CSP) developmentally complex, not necessarily pathological, possibly pervasive, cell or humoral immune system reactivity toward autologous (self) antigens; do not confuse with AUTOIMMUNE DISORDER.
Concepts Pathologic Function (T046)
MSH D015551
SnomedCT 4301008
English Autoimmunities, Autoimmunity, self recognition (immune), autoimmunity, autoimmunities, Autoimmune state (finding), Autoimmune state, Autoimmune state, NOS, Autoimmunity, NOS, Autoimmune Status
Swedish Autoimmunitet
Czech autoimunita
Finnish Autoimmuniteetti
French Auto-immunité, Autoimmunité
Russian AUTOIMMUNITET, АУТОИММУНИТЕТ
Spanish estado autoinmunitario (hallazgo), estado autoinmune (hallazgo), estado autoinmunitario, estado autoinmune, autoinmunidad, Autoinmunidad
Portuguese Autoimunidade, Reação Autoimune
Croatian AUTOIMUNOST
Polish Odpowiedź autoimmunizacyjna, Autoodporność, Odpowiedź autoodpornościowa
Norwegian Autoimmunitet
German Autoimmunisierung
Dutch Auto-immuniteit
Italian Autoimmunità