Antithyroid Antibody

Aka: Antithyroid Antibody, Thyroid Autoantibody, TSH Receptor Antibody, Anti TSH receptor antibody, TSHrAb, Thyroid Stimulating Immunoglobulin, Antithyroid Microsomal Antibody, Antithyroid Peroxidase Antibody, Antithyroglobulin Antibody, Thyroglobulin Antibody, TPO Antibody

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II. Measurement

  1. Bioassay

III. Labs: Thyroid Stimulating Immunoglobulin (TSH receptor ab)

  1. Binds and activates TSH receptor in Thyroid
  2. Linked with Grave's ophthalmopathy
  3. Sensitive and Specific for Grave's Disease as a cause of Hyperthyroidism
    1. Test Sensitivity: 97%
    2. Test Specificity: >=98%

IV. Labs: Antithyroid Microsomal Antibody (TMAb) or Antithyroid Peroxidase Antibody (TPO Antibody)

  1. Seen in Autoimmune Thyroiditis
    1. Hashimoto's Thyroiditis
    2. Subacute Thyroiditis
    3. Silent Thyroiditis
    4. Postpartum Thyroiditis

V. Labs: Antithyroglobulin Antibody (TgAb)

  1. Seen in Hashimoto's Thyroiditis
  2. Less commonly elevated compared with TMAb

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