II. Measurement

  1. Measures responsiveness of pituitary to TRH

III. Protocol

  1. Administer TRH 500 ug
  2. Measure Thyroid Stimulating Hormone (TSH) at 30-60 min

IV. Interpretation: TSH

  1. Normal Response
    1. TSH rises 2-4x baseline
  2. Hyperthyroidism
    1. Low TSH with suppressed response to TRH
  3. Hypothyroidism
    1. High TSH with exaggerated TRH response

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