II. Physiology

  1. Glycoprotein produced primarily in liver, as well as sertoli cells (Testes), Uterus, placenta, brain
  2. Sex Hormone Binding Globulin (SHBG) binds 17 beta-hydroxysteriod Hormones: androgens (e.g. Testosterone) and Estrogen
  3. Transcortin, by contrast binds other steroid Hormones (Progesterone, Corticosteroids)

III. Interpretation: Normal Levels

  1. Male: 0.4 to 1.3 ug DHT/100 ml
  2. Female: 0.4 to 3.5 ug DHT/100 ml
  3. Pregnancy: 6.5 to 9.7 ug DHT/100 ml

IV. Causes: Increased SHBG (lower, unbound, Free Testosterone)

  1. Oral Contraceptives
  2. Pregnancy
  3. Hyperthyroidism
  4. Cirrhosis
  5. Anorexa nervosa (or other longterm low calorie intake)
  6. Advancing age
    1. See Androgen Decline in the Aging Male

V. Causes: Decreased SHBG (higher, unbound, Free Testosterone)

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Related Studies

Ontology: Sex Hormone-Binding Globulin (C0036883)

Definition (NCI) Expressed as 2 alternative isoforms in Sertoli cells and liver by human SHBG Gene, 402-aa 44-kDa (precursor) homodimeric Sex Hormone-Binding Globulin is a secreted beta-globulin plasma glycoprotein containing 2 laminin G-like domains that specifically bind 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)
Definition (MSH) A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D012738
SnomedCT 55503002
LNC LP15863-1, MTHU004559
English Binding Globulin, Testosterone-Estradiol, Globulin, Sex Hormone-Binding, Globulin, Testosterone-Estradiol Binding, Hormone-Binding Globulin, Sex, Sex Hormone Binding Globulin, Sex Hormone-Binding Globulin, Sex Steroid Binding Protein, Sex Steroid-Binding Protein, Steroid-Binding Protein, Sex, Testosterone-Estradiol Binding Globulin, SHBG- Sex horm bind globulin, Sex Hormone-Binding Globulin [Chemical/Ingredient], sex hormone binding globulin, sex hormone-binding globulin, sex hormone binding globulin (SHBG), shbg, GBG, Sex hormone binding globulin, Sex steroid binding globulin, SHBG - Sex hormone binding globulin, Sex steroid binding globulin (substance), Testosterone Estradiol Binding Globulin, SHBG, Testis-Specific Androgen-Binding Protein
Swedish Könshormonbindande globulin
Czech globulin vážící pohlavní hormony
Finnish Sukupuolihormoneja sitova globuliini
French Globuline fixant les hormones sexuelles, Globuline de transport des hormones sexuelles, SBP (Sex Steroid-Binding Protein), Globuline de fixation des hormones sexuelles, Globuline de liaison des hormones sexuelles, Globuline liant les hormones sexuelles, Globuline se liant aux hormones sexuelles, Protéine de transport des hormones sexuelles, Globuline de liaison aux hormones sexuelles, Protéine de liaison aux hormones stéroïdes sexuelles
Italian Globulina legante testosterone-estradiolo, Proteina legante ormoni sessuali steroidei, Globulina legante ormoni sessuali
Portuguese Globulina de Ligação a Testosterona e a Estradiol, Proteína de Ligação a Esteroide Sexual, Globulina Ligante de Testosterona e Estradiol, Globulina Ligante de Hormônio Sexual, Proteína Ligante de Esteroide Sexual, Globulina de Ligação a Hormônio Sexual
Polish Globuliny wiążące hormony płciowe
Japanese 性ステロイド結合蛋白質, 性ホルモン結合グロブリン, テストステロンエストラジオール結合グロブリン, 性ホルモン結合性グロブリン
Spanish proteína fijadora de esteroides sexuales (sustancia), proteína fijadora de esteroides sexuales, Globulina de Unión a Estradiol Testosterona, Globulina de Unión a Hormona Sexual, Proteína de Unión a Esteroide Sexual
German Geschlechtshormonbindendes Globulin, Sexualhormonbindendes Globulin, Sexualsteroidbindendes Globulin, Testosteron-Estradiol-bindendes Globulin, Estradiol-bindendes Globulin, Globulin, Estradiol-bindendes, Globulin, Testosteron-bindendes, Testosteron-bindendes Globulin