II. Causes
- More than 80 drugs associated (first described in 1945 related to Sulfadiazine)
- Hydralazine (most common cause)
- Procainamide
- Isoniazid
- Minocycline
- Terbinafine
- Phenytoin (Dilantin)
- Ethosuximide
- D-Penicillamine
- Proton Pump Inhibitors
- Beta Blockers
III. Symptoms (following causative medication use)
- See Systemic Lupus Erythematosus
- Arthralgias
- Rash
- Serositis
- Hematologic abnormalities
IV. Labs
- Screening indicated for causative medication use and symptoms suggestive of SLE (see above)
- ANA Titer
- Confirmatory testing if positive ANA titer
- Antihistone Antibody
- Test Sensitivity in drug induced lupus: 95%
- Test Specificity in drug induced lupus: >90%
- Antihistone Antibody
V. Prognosis
- Symptoms often recede with stopping causative agent
- Rarely life threatening
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Definition (NCI) | An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs. |
Concepts | Pathologic Function (T046) |
ICD10 | M32.0 |
SnomedCT | 201436003, 80258006 |
English | Drug-ind systemic lupus eryth, drug induced systemic lupus erythematosus, drug induced systemic lupus erythematosus (diagnosis), drug-induced lupus, lupus drug induced, lupus drug-induced, drug induced lupus, drug induced lupus erythematosus, Drug Induced Lupus, Drug Induced Lupus Erythematosus, Drug-induced systemic lupus erythematosus, Drug-induced lupus erythematosus, Drug-induced lupus erythematosus (disorder), Drug-induced systemic lupus erythematosus (disorder), SLE; drug, drug; SLE, Drug-induced lupus erythematosus, NOS |
Dutch | geneesmiddelgeïnduceerde lupus erythematosus, LED; geneesmiddel, geneesmiddel; LED, Door geneesmiddel geïnduceerde lupus erythematodes disseminatus [LED] |
French | Lupus érythémateux d'origine médicamenteuse |
German | von Arzneimitteln verursachter Lupus erythematosus, Arzneimittelinduzierter systemischer Lupus erythematodes |
Italian | Lupus eritematoso da farmaci |
Portuguese | Lúpus eritematoso farmacoinduzido |
Spanish | Lupus eritematoso inducido por fármacos, lupus eritematoso farmacógeno, lupus eritematoso medicamentoso (trastorno), lupus eritematoso medicamentoso, lupus eritematoso sistémico medicamentoso (trastorno), lupus eritematoso sistémico medicamentoso |
Japanese | 薬剤誘発性エリテマトーデス, ヤクザイユウハツセイエリテマトーデス |
Czech | Léky vyvolaný lupus erytematosus |
Korean | 약물 유발성 전신 홍반성 루푸스 |
Hungarian | Gyógyszer-által kiváltott lupus erythematosus |
Ontology: Lupus-like syndrome (C0919715)
Concepts | Disease or Syndrome (T047) |
Italian | Sindrome simil-lupoide |
Japanese | ループス様症候群, ループスヨウショウコウグン |
Czech | Lupus-like syndromy |
English | lupus-like syndrome, Lupus-like syndrome |
Hungarian | Lupus-szerű syndroma |
Portuguese | Síndrome do tipo Lupus |
Spanish | Síndrome tipo lupus |
Dutch | lupusachtig syndroom |
French | Syndrome de type lupus |
German | Lupus-aehnliches Syndrom |