II. Background
- Produced first in 1958 from penicillium
III. Indications
IV. Duration
-
Tinea Capitis
- Treated for 6-8 weeks (durations up to 16 weeks have been used previously) or
- Two weeks after cultures are negative
V. Efficacy
- Very effective for Tinea Capitis over 2-4 months
- Not as effective for Tinea Unguium
VI. Dosing
- Ultrasize preparations are also available but are significantly more expensive (but better absorption)
- Griseofulvin microsize (Griseofulvin V)
- Adults: 500 mg (up to 1 g) orally daily
- Child: 10-20 mg/kg/day (up to 20-25 mg/kg/day, maximum 1 g/day) until Hair Growth
VII. Monitoring
- No baseline testing needed in the absence of liver disease
- Obtain labs for treatment duration >8 weeks (or history of abnormal Liver Function Tests)
- Liver Function Tests (ALT, AST, Serum Bilirubin) every 8 weeks
- Complete Blood Count (CBC) every 8 weeks
- Serum Creatinine every 8 weeks
VIII. Directions
- Take with food (especially a fatty meal) for better absorption
IX. References
Images: Related links to external sites (from Bing)
Related Studies (from Trip Database) Open in New Window
| griseofulvin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GRISEOFULVIN 125 MG/5 ML SUSP | Generic | $0.19 per ml |
| GRISEOFULVIN MICRO 500 MG TAB | Generic | $6.36 each |
| GRISEOFULVIN ULTRA 125 MG TAB | Generic | $3.17 each |
| GRISEOFULVIN ULTRA 250 MG TAB | Generic | $4.25 each |
Ontology: Griseofulvin (C0018242)
| Definition (NCI) | An antifungal agent derived from the mold Penicillium griseofulvum that is used to treat fungal infections of the skin and nails. Griseofulvin binds to tubulin, disrupting microtubule function and inhibiting mitosis. |
| Definition (MSH) | An antifungal agent used in the treatment of TINEA infections. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D006118 |
| SnomedCT | 372807004, 64349004 |
| LNC | LP18091-6, MTHU003374 |
| English | Griseofulvin, Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-, griseofulvin, griseofulvin (medication), Griseofulvin [Chemical/Ingredient], GRISEOFULVIN, Griseofulvin (product), Griseofulvin (substance) |
| Swedish | Griseofulvin |
| Czech | griseofulvin |
| Finnish | Griseofulviini |
| Russian | GRIZEOFUL'VIN, ГРИЗЕОФУЛЬВИН |
| Japanese | グリセオフルビン |
| Croatian | GRIZEOFULVIN |
| Polish | Likuden, Fulcyna, Gryzeofulwina |
| Spanish | griseofulvina (producto), griseofulvina (sustancia), griseofulvina, Griseofulvina |
| French | Griséofulvine |
| German | Griseofulvin |
| Italian | Griseofulvin |
| Portuguese | Griseofulvina |
