II. Background
- Produced first in 1958 from penicillium
III. Indications
IV. Duration
-
Tinea Capitis
- Treated for 6-8 weeks (durations up to 16 weeks have been used previously) or
- Two weeks after cultures are negative
V. Efficacy
- Very effective for Tinea Capitis over 2-4 months
- Not as effective for Tinea Unguium
VI. Dosing
- Ultrasize preparations are also available but are significantly more expensive (but better absorption)
- Griseofulvin microsize (Griseofulvin V)
- Adults: 500 mg (up to 1 g) orally daily
- Child: 10-20 mg/kg/day (up to 20-25 mg/kg/day, maximum 1 g/day) until Hair Growth
VII. Monitoring
- No baseline testing needed in the absence of liver disease
- Obtain labs for treatment duration >8 weeks (or history of abnormal Liver Function Tests)
- Liver Function Tests (ALT, AST, Serum Bilirubin) every 8 weeks
- Complete Blood Count (CBC) every 8 weeks
- Serum Creatinine every 8 weeks
VIII. Directions
- Take with food (especially a fatty meal) for better absorption
IX. References
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Related Studies
| griseofulvin (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GRISEOFULVIN 125 MG/5 ML SUSP | Generic | $0.41 per ml |
| GRISEOFULVIN MICRO 500 MG TAB | Generic | $7.40 each |
| GRISEOFULVIN ULTRA 250 MG TAB | Generic | $4.45 each |