II. Indications
- See First Generation Cephalosporin
- Skin and Soft Tissue Infection
- Surgical Prophylaxis
- Endocarditis
- Uncomplicated Urinary Tract Infection
- SBE Prophylaxis
III. Mechanism
IV. Dosing: Adult
- Mild to Moderate Infections
- Give 0.5 to 1 g IM or IV every 6 to 8 hours
- Severe Infections
- Give 1 to 1.5 g IM or IV every 6 hours
- Loading Dose protocol
- Give 2 g IM or IV, then 1 g every 6 to 8 hours
-
Renal Dosing
- eGFR 35 to 54 ml/min: Dose every 8 hours
- eGFR 10 to 35 ml/min: 50% of typical dose every 12 hours
- eGFR <10 ml/min: Give first typical dose, then 50% of typical dose every 18 to 24 hours
V. Dosing: Child (age >1 month)
- Mild to Moderate Infections (Typical Dosing)
- Give 25 to 50 mg/kg/day divided every 6 to 8 hours
- Severe Infections
- Give 100 mg/kg/day divided every 6 to 8 hours
- Maximum: 2 grams per dose
-
Renal Dosing
- eGFR 40 to 70 ml/min: 60% of typical dose every 12 hours
- eGFR 20 to 40 ml/min: 25% of typical dose every 12 hours
- eGFR 5 to 20 ml/min: Give first typical dose, then 10% of typical dose every 24 hours
VI. Safety
- Pregnancy Category B (All Trimesters)
- Safe in Lactation
VII. Resources
VIII. References
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
- Hamilton (2020) Tarascon Pocket Pharmacopoeia