II. Indications
- See First Generation Cephalosporin
- Skin and Soft Tissue Infection
- Surgical Prophylaxis
- Endocarditis
- Uncomplicated Urinary Tract Infection
- SBE Prophylaxis
III. Mechanism
IV. Dosing: Adult
- Mild to Moderate Infections
- Give 0.5 to 1 g IM or IV every 6 to 8 hours
- Severe Infections
- Give 1 to 1.5 g IM or IV every 6 hours
- Loading Dose protocol
- Give 2 g IM or IV, then 1 g every 6 to 8 hours
-
Renal Dosing
- eGFR 35 to 54 ml/min: Dose every 8 hours
- eGFR 10 to 35 ml/min: 50% of typical dose every 12 hours
- eGFR <10 ml/min: Give first typical dose, then 50% of typical dose every 18 to 24 hours
V. Dosing: Child (age >1 month)
- Mild to Moderate Infections (Typical Dosing)
- Give 25 to 50 mg/kg/day divided every 6 to 8 hours
- Severe Infections
- Give 100 mg/kg/day divided every 6 to 8 hours
- Maximum: 2 grams per dose
-
Renal Dosing
- eGFR 40 to 70 ml/min: 60% of typical dose every 12 hours
- eGFR 20 to 40 ml/min: 25% of typical dose every 12 hours
- eGFR 5 to 20 ml/min: Give first typical dose, then 10% of typical dose every 24 hours
VI. Safety
- Pregnancy Category B (All Trimesters)
- Safe in Lactation
VII. Resources
VIII. References
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
Definition (NCI) | A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
Definition (MSH) | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D002437 |
SnomedCT | 323932006, 81088002, 387470007 |
LNC | LP16066-0, MTHU005579 |
English | Cefazolin, Cephazolin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-, (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Cefazolin [Chemical/Ingredient], cephazolin, ceFAZolin, CEFAZOLIN, cefazolin, Cephazolin (product), Cephazolin (substance) |
Swedish | Cefazolin |
Czech | cefazolin |
Finnish | Kefatsoliini |
Russian | TSEFAZOLIN, ЦЕФАЗОЛИН |
Japanese | セファゾリン, セファゾリンナトリウム |
Polish | Cefazolina |
Spanish | cefazolina (producto), cefazolina (sustancia), cefazolina, Cefazolina |
French | Céfazoline |
German | Cefazolin, Cephazolin |
Italian | Cefazolina |
Portuguese | Cefazolina |
Ontology: Ancef (C0700926)
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D002437 |
English | ancef, Ancef |