II. Indications

III. Mechanism

IV. Dosing: Adult

  1. Mild to Moderate Infections
    1. Give 0.5 to 1 g IM or IV every 6 to 8 hours
  2. Severe Infections
    1. Give 1 to 1.5 g IM or IV every 6 hours
  3. Loading Dose protocol
    1. Give 2 g IM or IV, then 1 g every 6 to 8 hours
  4. Renal Dosing
    1. eGFR 35 to 54 ml/min: Dose every 8 hours
    2. eGFR 10 to 35 ml/min: 50% of typical dose every 12 hours
    3. eGFR <10 ml/min: Give first typical dose, then 50% of typical dose every 18 to 24 hours

V. Dosing: Child (age >1 month)

  1. Mild to Moderate Infections (Typical Dosing)
    1. Give 25 to 50 mg/kg/day divided every 6 to 8 hours
  2. Severe Infections
    1. Give 100 mg/kg/day divided every 6 to 8 hours
  3. Maximum: 2 grams per dose
  4. Renal Dosing
    1. eGFR 40 to 70 ml/min: 60% of typical dose every 12 hours
    2. eGFR 20 to 40 ml/min: 25% of typical dose every 12 hours
    3. eGFR 5 to 20 ml/min: Give first typical dose, then 10% of typical dose every 24 hours

VI. Safety

  1. Pregnancy Category B (All Trimesters)
  2. Safe in Lactation

VIII. References

  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Definition (NCI) A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002437
SnomedCT 323932006, 81088002, 387470007
LNC LP16066-0, MTHU005579
English Cefazolin, Cephazolin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-, (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Cefazolin [Chemical/Ingredient], cephazolin, ceFAZolin, CEFAZOLIN, cefazolin, Cephazolin (product), Cephazolin (substance)
Swedish Cefazolin
Czech cefazolin
Finnish Kefatsoliini
Russian TSEFAZOLIN, ЦЕФАЗОЛИН
Japanese セファゾリン, セファゾリンナトリウム
Polish Cefazolina
Spanish cefazolina (producto), cefazolina (sustancia), cefazolina, Cefazolina
French Céfazoline
German Cefazolin, Cephazolin
Italian Cefazolina
Portuguese Cefazolina

Ontology: Ancef (C0700926)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002437
English ancef, Ancef