II. Indications

  1. Impetigo
  2. MRSA nasal carriage

III. Mechanism

  1. Topical Antibiotic extracted from Pseudomonas fluorescens
  2. Inhibits Bacterial Protein synthesis
    1. BInds reversibly and specifically to Bacterial isoleucyl tRNA synthase
  3. Active against Gram Positive Bacteria, Streptococcus and Staphylococcus (including MRSA)

IV. Dosing

  1. May be used in age 2 months and older
  2. Available as 22 g tube (ointment is less expensive than creams)
  3. Impetigo
    1. Apply Mupirocin 2% ointment three times daily to affected area for 7-10 days

V. Efficacy

  1. Emerging Streptococcal resistance in 2014

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Related Studies

Cost: Medications

mupirocin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MUPIROCIN 2% CREAM Generic $2.75 per gram
MUPIROCIN 2% OINTMENT Generic $0.17 per gram

Ontology: Mupirocin (C0085259)

Definition (NCI) A natural crotonic acid derivative extracted from Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl tRNA synthase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. (NCI04)
Definition (MSH) A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Concepts Lipid (T119) , Antibiotic (T195)
MSH D016712
SnomedCT 387397004, 71453003
LNC LP17279-8, MTHU009172
English Acid, Pseudomonic, Mupirocin, Pseudomonic Acid, Pseudomonic Acid A, Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-, mupirocin, mupirocin (medication), MUPIROCIN, Mupirocin [Chemical/Ingredient], pseudomonic acid a, Pseudomonic acid, Pseudomonic acid A, Mupirocin (product), Mupirocin (substance)
Swedish Mupirocin
Czech mupirocin
Finnish Mupirosiini
Russian MUPIROTSIN, PSEVDOMONOVAIA KISLOTA, МУПИРОЦИН, ПСЕВДОМОНОВАЯ КИСЛОТА
Italian Acido pseudomonico, Acido pseudomonico A, Mupirocina
Polish Mupirocyna, Kwas pseudomonowy
Japanese プソイドモニックアシド, ムピロシン
Spanish Ácido Pseudomónico, mupirocina (producto), mupirocina (sustancia), mupirocina, ácido pseudomónico A, ácido pseudomónico, ácido seudomónico, Mupirocina, Ácido Seudomónico
French Acide pseudomonique, Mupirocine
German Mupirocin, Pseudomonassäure
Portuguese Ácido Pseudomônico, Mupirocina

Ontology: Bactroban (C0733863)

Concepts Lipid (T119) , Antibiotic (T195)
MSH D016712
English bactroban, Bactroban