II. Indications

III. Contraindications

  1. Active Infection (e.g. EBV, CMV, HSV, VZV)

IV. Mechanism

  1. Horse serum IgG extract
  2. Suppresses both T Cell and Humoral Immunity

V. Dosing

  1. See other references
  2. Precautions
    1. Although only FDA approved in adults, has been used in children safely (at same weight-based dose)
    2. Infuse over at least 4 hours
    3. Must be infused with intravenous line filter (contains insoluble components)
    4. Consider coadministration of Corticosteroids to prevent Anaphylaxis
  3. Renal Allograft rejection
    1. Infuse 10 to 15 mg/kg daily IV over 4 hours for 14 days
  4. Aplastic Anemia
    1. Infuse 10 to 20 mg/kg daily IV over 4 hours for 8 to 14 days

VI. Adverse Effects

  1. Anaphylaxis (<1% of patients within first 24 hours, black box warning)
  2. Serum Sickness
  3. Cytokine Release Syndrome
  4. Hematologic
    1. Leukopenia
    2. Thrombocytopenia
  5. Common
    1. Fever and chills
    2. Rash
  6. Uncommon
    1. Nausea and Vomiting
    2. Chest Pain
    3. Back Pain
    4. Arthralgias
    5. Night Sweats
    6. Headache

VII. Safety

  1. Unknown safety in Lactation
  2. Pregnancy Category C
    1. May use in pregnancy if benefit outweighs risk
    2. Men and women should prevent pregnancy with reliable Contraception for 10 weeks after dose

VIII. Drug Interactions

  1. Live Attenuated Vaccine
    1. Avoid with Lymphocyte Immune Globulin

IX. Resources

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Horse antihuman thymocyte gamma globulin (C0359163)

Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
SnomedCT 67213005
English Eq anti-hum thym immunoglob, Horse antihuman thymocyte gamma globulin, Equine anti-human thymocyte immunoglobulin, Equine antithymocyte globulin
Spanish gammaglobulina antitimocito humano equina, globulina antitimocito equina

Ontology: thymocyte immunoglobulin, equine (C2756957)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) , Pharmacologic Substance (T121)
English EQUINE THYMOCYTE IMMUNE GLOBULIN, Equine Thymocyte Immune Globulin, Equine Anti-human Thymocyte Immunoglobulin, Lymphocyte Immune Globulin, Anti-Thymocyte Globulin, thymocyte immunoglobulin, equine

Ontology: lymphocyte immune globulin, anti-thymocyte (equine) (C2920496)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) , Pharmacologic Substance (T121)
English lymphocyte immune globulin, anti-thymocyte (equine)