II. Indications

  1. Fascioliasis
    1. Liver Fluke or Flatworm Infection

III. Medications

  1. Triclabendazole 250 mg tablets
    1. May be taken whole or divided
    2. May be crushed and mixed with apple sauce (take within 4 hours)

IV. Mechanism

  1. Antihelminth in the benzimidazole family of drugs
  2. Binds beta-tubulin and prevents microtubule polymerization
    1. Inhibits Helminth reproduction and survival

V. Dosing: Adult (and child age >=6 years)

  1. Triclabendazole 10 mg/kg orally with food every 12 hours for 2 doses

VII. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

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