Antiparasitic Agent

Aka: Antiparasitic Agent, Parasiticidal Medication, Parasiticide, Antiparasitic, Antiprotozoal Agent, Antiprotozoal, Antiprotozoal Drug

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II. Medications: Protozoa

  1. Malaria
    1. Heme Detoxification Modulators (e.g. Amodiaquine, Artemisinins, Lumefantrine, Chloroquine, Mefloquine, Quinine)
    2. Doxycycline
    3. Miscellaneous (e.g. Atovaquone-proguanil, Primaquine)
  2. Babesia
    1. Mitochondrial electron transport inhibitor (e.g. Atovaquone)
    2. Parasite apicoplast organelle targeting (e.g. Azithromycin, Clindamycin)
    3. Miscellaneous (e.g. Quinine)
  3. Amoebiasis
    1. Protein synthesis inhibitor (e.g. Paromomycin, Emetine)
    2. Promote toxic metabolite formation (e.g. Metronidazole, Tinidazole)
    3. Protozoal metabolism targeted (e.g. Iodoquinol)
    4. Miscellaneous (e.g. Diloxanide Furoate)
  4. Leishmaniasis
    1. Protein synthesis inhibitor (e.g. Paromomycin)
    2. Energy Metabolism Disruption (e.g. Pentamidine, Sodium stibogluconate, Meglumine antimoniate)
    3. Cell Membrane disruption (Amphotericin B)
  5. American Trypanosomiasis (Chagas Disease)
    1. Promote toxic metabolite formation (e.g. Benznidazole, Nifurtimox)
  6. West African trypanosomiasis
    1. Energy Metabolism Disruption (e.g. Pentamidine, Suramin)
    2. Miscellaneous (e.g. Eflornithine, Melarsoprol )
  7. Toxoplasmosis
    1. DNA and Protein synthesis inhibitor (e.g. Pyrimethamine-Sulfadiazine)

III. Medications: Helminths

  1. Tapeworms (Cestodes, e.g. Echinococcosis, Cysticercosis)
    1. Ion transport disruption (e.g. Praziquantel)
    2. Energy Metabolism Disruption (e.g. Niclosamide)
    3. Microtube Disruption (e.g. Albendazole)
  2. Flukes (Trematodes, e.g. Schistosomiasis)
    1. Ion transport disruption (e.g. Praziquantel)
    2. Animetabolite (e.g. Oxamniquine)
    3. Microtube Disruption (e.g. Triclabendazole)
    4. Energy Metabolism Disruption (e.g. Bithionol)
    5. Neuromuscular Blockade (e.g. Metrifonate)
  3. Roundworms (Nematodes, e.g. Pinworm, Trichinosis,Toxocariasis, Strongyloides)
    1. Gastrointestinal infections
      1. Microtube Disruption (e.g. Albendazole, Mebendazole)
      2. Neuromuscular Blockade (e.g. Pyrantel Pamoate, Ivermectin)
    2. Tissue Infections
      1. Phagocytosis mediator (e.g. Diethylcarbamazine)
      2. Energy Metabolism Disruption (e.g. Suramin)
      3. Ion transport disruption (e.g. Praziquantel)

IV. Medications: Ectoparasites (e.g. Scabies, Lice)

  1. Neurotoxins
    1. Pyrethroids (e.g. Pyrethrin, Permethrin)
    2. Benzyl benzoate
  2. GABA Receptor modulators
    1. Lindane
    2. Ivermectin

V. Resources

  1. Campbell (2023) Antiparasitic Drugs, StatPearls, Treasure Island, FL
    1. https://www.ncbi.nlm.nih.gov/books/NBK544251/

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