II. Indications
- Activity spectrum
- Gram Positive Bacteria
- Anaerobic Bacteria infection
- No activity against Gram Negative Bacteria
- Conditions (FDA approved)
- Conditions (off-label)
- Orofacial infections
- Bacterial Vaginosis
- Streptococcal Pharyngitis (in Penicillin allergic patients)
- Malaria
- Anthrax
- Babesiosis
III. Mechanism
IV. Dosing: General
- Take capsules with water to prevent esophageal irritation
- May take with or without food
- Reduce dose in hepatic dysfunction
V. Dosing: Adult
- Oral
- Moderate infections: 300 to 450 mg orally three to four times daily
- Severe or complicated infections: 600 mg orally three times daily
- IV: 600 to 900 mg IV every 8 hours
- IM: up to 600 mg every 8 hours
VI. Dosing: Child
-
Preterm Infant
- IV: 15 mg/kg/day IV divided three times daily
- Term Infants < 1 month
- IV: 15 to 20 mg/kg/day IV divided three times daily
- Child
- IV: 20 to 40 mg/kg/day IV divided every 6 to 8 hours
- PO: 8 to 20 mg/kg/day orally divided three to four times daily
VII. Pharmacokinetics
- Both renal and hepatic excretion
- Actively transported into abscesses
- Does not enter cerebrospinal fluid
VIII. Adverse Effects
- Abdominal cramping
- Diarrhea
-
Pseudomembranous colitis (Clostridioides difficile)
- Although most systemic Antibiotics risk C. diff, Clindamycin has been most associated
IX. Safety
- Considered safe in pregnancy
- Considered safe in Lactation
X. Drug Interactions
-
CYP3A4 Inducers
- Decrease Clindamycin serum levels
XI. Resources
- Clindamycin Phosphate Injection (DailyMed)
- Clindamycin Hydrochloride Capsule (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| clindamycin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CLINDAMYCIN (PEDI) 75 MG/5 ML | Generic | $0.19 per ml |
| CLINDAMYCIN 2% VAGINAL CREAM | Generic | $1.62 per gram |
| CLINDAMYCIN HCL 150 MG CAPSULE | Generic | $0.11 each |
| CLINDAMYCIN HCL 300 MG CAPSULE | Generic | $0.26 each |
| CLINDAMYCIN HCL 75 MG CAPSULE | Generic | $0.33 each |
| CLINDAMYCIN PH 1% GEL | Generic | $0.46 per gram |
| CLINDAMYCIN PH 1% SOLUTION | Generic | $0.28 per ml |
| CLINDAMYCIN PHOS 1% PLEDGET | Generic | $0.31 each |
| CLINDAMYCIN PHOSP 1% LOTION | Generic | $0.50 per ml |
| CLINDAMYCIN PHOSPHATE 1% FOAM | Generic | $4.51 per gram |
| CLINDAMYCIN PHOSPHATE 1% GEL | Generic | $9.41 per ml |
| CLINDAMYCIN-BENZOYL PEROX 1-5% | Generic | $0.73 per gram |
| CLINDAMYCIN-BNZ PEROX 1-5% PMP | Generic | $1.46 per gram |
| cleocin (on 3/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CLEOCIN 100 MG VAGINAL OVULE | $58.57 each | |
| CLEOCIN T 1% LOTION | Generic | $0.50 per ml |
Ontology: Clindamycin (C0008947)
| Definition (CHV) | an antibacterial drug |
| Definition (CHV) | an antibacterial drug |
| Definition (NCI) | A semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04) |
| Definition (MSH) | An antibacterial agent that is a semisynthetic analog of LINCOMYCIN. |
| Concepts | Antibiotic (T195) , Carbohydrate (T118) |
| MSH | D002981 |
| SnomedCT | 370443009, 332356004, 372786004, 58883005 |
| LNC | LP15427-5, MTHU006899 |
| English | 7 Chloro 7 deoxylincomycin, 7-Chloro-7-deoxylincomycin, Chlolincocin, Chlorlincocin, Clindamycin, L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-, Clindamycin [skin], Clindamycin [Chemical/Ingredient], clindamicin, CLINDAMYCIN, Clindamycin product (product), Clindamycin [skin] (product), clindamycin, Clindamicin, Clindamycin product, Clindamycin (product), Clindamycin (substance), Clindamycin [skin] (substance) |
| Swedish | Klindamycin |
| Czech | klindamycin |
| Finnish | Klindamysiini |
| Russian | KLINDAMITSIN, КЛИНДАМИЦИН |
| Japanese | クリンダマイシン |
| Italian | 7-Cloro7-deossi lincomicina, Clindamicina |
| Croatian | KLINDAMICIN |
| Polish | Klindamycyna |
| Spanish | producto con clindamicina (producto), clindamicina (uso dermatológico) (producto), clindamicina (uso dermatológico), producto con clindamicina, clindamicina (piel) (producto), clindamicina (piel), clindamicina (producto), clindamicina (sustancia), clindamicina, Clindamicina |
| French | Clindamycine |
| German | Clindamycin |
| Portuguese | Clindamicina |
Ontology: Cleocin (C0699673)
| Concepts | Antibiotic (T195) , Carbohydrate (T118) |
| MSH | D002981 |
| English | cleocin, Cleocin |
Ontology: Lincosamide Antibiotic (C2826567)
| Definition (NCI) | Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death. |
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| English | Lincosamide Antibiotic |
