II. Indications
- Activity spectrum
- Gram Positive Bacteria
- Anaerobic Bacteria infection
- No activity against Gram Negative Bacteria
- Conditions (FDA approved)
- Conditions (off-label)
- Orofacial infections
- Bacterial Vaginosis
- Streptococcal Pharyngitis (in Penicillin allergic patients)
- Malaria
- Anthrax
- Babesiosis
III. Mechanism
IV. Dosing: General
- Take capsules with water to prevent esophageal irritation
- May take with or without food
- Reduce dose in hepatic dysfunction
V. Dosing: Adult
- Oral
- Moderate infections: 300 to 450 mg orally three to four times daily
- Severe or complicated infections: 600 mg orally three times daily
- IV: 600 to 900 mg IV every 8 hours
- IM: up to 600 mg every 8 hours
VI. Dosing: Child
-
Preterm Infant
- IV: 15 mg/kg/day IV divided three times daily
- Term Infants < 1 month
- IV: 15 to 20 mg/kg/day IV divided three times daily
- Child
- IV: 20 to 40 mg/kg/day IV divided every 6 to 8 hours
- PO: 8 to 20 mg/kg/day orally divided three to four times daily
VII. Pharmacokinetics
- Both renal and hepatic excretion
- Actively transported into abscesses
- Does not enter cerebrospinal fluid
VIII. Adverse Effects
- Abdominal cramping
- Diarrhea
-
Pseudomembranous colitis (Clostridioides difficile)
- Although most systemic Antibiotics risk C. diff, Clindamycin has been most associated
IX. Safety
- Considered safe in pregnancy
- Considered safe in Lactation
X. Drug Interactions
-
CYP3A4 Inducers
- Decrease Clindamycin serum levels
XI. Resources
- Clindamycin Phosphate Injection (DailyMed)
- Clindamycin Hydrochloride Capsule (DailyMed)
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Related Studies
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| CLINDAMYCIN (PEDI) 75 MG/5 ML | Generic | $0.19 per ml |
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| cleocin (on 3/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
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