II. Indications
- Skin disorders
- Gastrointestinal disorders
- Helicobacter Pylori (part of quadruple therapy protocol)
- Tick-borne illness
- Miscellaneous disorders
- Sexually Transmitted Disease
III. Contraindications
- Pregnancy
- Pregnancy category D
- Children under age 8 years old
- AAP now approves Doxycycline for ANY age up to 21 day duration
- Unlike Tetracycline, Doxycycline is unlikely to cause visible tooth staining
- For severe infections (e.g. Lyme Disease, Rocky Mountain Spotted Fever), Doxycycline is a first-line agent
IV. Mechanism
- See Tetracycline
- Tetracyclines are bacteriostatic Protein synthesis inhibitors, binding the 30S ribosomal subunit of susceptible Bacteria
- Prevents elongated peptide chains from forming from Amino Acid residues
- Inhibits Amino Acid-linked tRNA from binding at the Ribosomal A Site
V. Dosing
-
Acne Vulgaris
- Take 1 gram divided two to four times orally daily
VI. Pharmacokinetics
- Does not penetrate CSF
- Concentrated by the liver via enterohepatic circulation
- Excreted in urine and stool
VII. Precautions
- Use Sunscreen with these agents due to Drug-induced Photosensitivity
-
Pill Esophagitis
- Take with a full glass of water
VIII. Adverse Effects
- Photosensitivity
- Interferes with OCP action
-
Tooth Discoloration (Children under age 8 years)
- Tooth enamel hypoplasia
- Rare with Doxycycline
-
Pseudotumor Cerebri
- Rare Tetracycline class effect
IX. Safety
- Pregnancy Category D
- Unknown safety in Lactation
X. Drug Interactions
- Food
- Milk and Calcium-rich food decrease absorption
- Take 1 hour before or 2 hours after a meal
- Take with a full glass of water (risk of Pill Esophagitis)
-
Warfarin
- Increases INR
XI. Resources
XII. References
- (2019) Tarascon Pharmacopeia, accessed 3/31/2019
- LoVecchio (2019) Crit Dec Emerg Med 33(3): 28
Images: Related links to external sites (from Bing)
Related Studies
| tetracycline (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TETRACYCLINE 250 MG CAPSULE | Generic | $0.66 each |
| TETRACYCLINE 500 MG CAPSULE | Generic | $0.95 each |
Ontology: Tetracycline (C0039644)
| Definition (NCI) | A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. |
| Definition (NCI_NCI-GLOSS) | A drug used to treat bacterial infections. It stops the growth of bacteria by keeping them from making proteins. Tetracycline also binds to new bone tissue and is being studied as a way to detect bone growth. Tetracycline is a type of antibiotic and a type of bone-labeling agent. |
| Definition (MSH) | A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D013752 |
| SnomedCT | 324010007, 372809001, 66261008 |
| LNC | LP16286-4, MTHU008490 |
| English | Tetracycline, 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-, Tetracycline [systemic], 4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide, tetracycline (medication), Tetracycline [Chemical/Ingredient], TETRACYCLINE, Tetracycline [systemic] (product), tetracycline, Tetracycline (product), Tetracycline (substance), TETRA, Tetracycline, NOS, Tetracycline [systemic] (substance), TCN |
| German | Tetrazyklin, Tetracyclin |
| Swedish | Tetracyklin |
| Czech | tetracyklin |
| Finnish | Tetrasykliini |
| Russian | TETRATSIKLIN, ТЕТРАЦИКЛИН |
| Japanese | 塩酸テトラサイクリン, コサテトラシン, テトラサイクリン塩酸塩, アクロマイシン, テトラサイクリン |
| Polish | Tetracyklina |
| Norwegian | Tetracyklin |
| Spanish | tetraciclina [sistémica], tetraciclina [sistémica] (producto), tetraciclina (producto), tetraciclina (sustancia), tetraciclina, Tetraciclina |
| French | Tétracycline |
| Italian | Tetraciclina |
| Portuguese | Tetraciclina |
