II. Indications

III. Mechanism

  1. See Acyclovir

IV. Medications

  1. Penciclovir 1% Cream

V. Dosing: Adults (and children age >12 years)

  1. Start topical application at first symptoms
  2. Apply every 2 hours while awake for 4 days

VI. Efficacy

  1. Study n=1573, PCT showed significant improvement
    1. More than 0.5 days faster resolution, decreased pain
  2. Reference
    1. Spruance (1997) JAMA 277:1374-9 [PubMed]

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Related Studies

Cost: Medications

penciclovir (on 2/22/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
PENCICLOVIR 1% CREAM Generic $107.44 per gram
denavir (on 6/22/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DENAVIR 1% CREAM $155.48 per gram