II. Indications
III. Mechanism
- See Acyclovir
IV. Medications
- Penciclovir 1% Cream
V. Dosing: Adults (and children age >12 years)
- Start topical application at first symptoms
- Apply every 2 hours while awake for 4 days
VI. Efficacy
- Study n=1573, PCT showed significant improvement
- More than 0.5 days faster resolution, decreased pain
- Reference
VII. Resources
VIII. References
Images: Related links to external sites (from Bing)
Related Studies
penciclovir (on 2/22/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
PENCICLOVIR 1% CREAM | Generic | $107.44 per gram |
denavir (on 6/22/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DENAVIR 1% CREAM | $155.48 per gram |
Ontology: penciclovir (C0164815)
Definition (NCI) | A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. |
Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
MSH | C053539 |
SnomedCT | 356191006, 333029001, 108918003, 386939003 |
LNC | LP101038-0, MTHU036238 |
English | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, penciclovir, Penciclovir [skin], penciclovir (medication), PENCICLOVIR, penciclovir [Chemical/Ingredient], 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-, 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Penciclovir [skin] (product), Penciclovir, Penciclovir (product), Penciclovir (substance), Penciclovir [skin] (substance) |
Spanish | penciclovir (uso dermatológico), penciclovir (uso dermatológico) (producto), penciclovir (piel) (producto), penciclovir (piel), penciclovir (producto), penciclovir (sustancia), penciclovir |
Ontology: Denavir (C0719742)
Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
MSH | C053539 |
English | Denavir, denavir, Vectavir, Novartis brand of penciclovir, SB-CH brand of penciclovir |