II. Indications
- Herpes Zoster (Shingles)
- Recurrent Genital Herpes
- Recurrent HSV in Immunocompromised patients
III. Mechanism
- See Acyclovir
IV. Dosing: Adult
-
Herpes Zoster (Shingles)
- Adult: 500 mg orally three times daily for 7 days
-
Genital Herpes
- Initial: 250 mg orally three times daily for 7-10 days
- Recurrent immunocompetent: 1000 mg orally twice daily for 2 days
- Prophylaxis: 250 mg orally twice daily for up to 12 months if more than 6 episodes per year
-
Orolabial Herpes
- Recurrent: 1500 mg orally for one dose at onset
- HIV (orolabial or genital)
- Recurrent: 500 mg orally twice daily for 7 days
- Renal
- Adjust dose for Creatinine Clearance <60 ml/min
VI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
VII. Resources
VIII. References
Images: Related links to external sites (from Bing)
Related Studies
| famciclovir (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| FAMCICLOVIR 125 MG TABLET | Generic | $0.32 each |
| FAMCICLOVIR 250 MG TABLET | Generic | $0.43 each |
| FAMCICLOVIR 500 MG TABLET | Generic | $0.88 each |
Ontology: famciclovir (C0209227)
| Definition (NCI) | A diacetyl 6-deoxy prodrug analog of the antiviral agent penciclovir. Orally administered, famciclovir in vivo is converted to penciclovir triphosphate, which is active against the Herpes viruses, including herpes simplex 1 and 2 and varicella-zoster. This agent inhibits the replication of viral DNA by interfering competitively with DNA polymerase. (NCI04) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C060590 |
| SnomedCT | 387557001, 96097002 |
| LNC | LP157326-2, MTHU045606 |
| English | 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine, famciclovir, famciclovir (medication), FAMCICLOVIR, famciclovir [Chemical/Ingredient], 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol Diacetate (ester), Famciclovir, Famciclovir product, Famciclovir (substance), Famciclovir (product) |
| Spanish | famciclovir (producto), famciclovir (sustancia), famciclovir |
Ontology: Famvir (C0591478)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C060590 |
| English | Famvir, famvir |
