Meropenem Vaborbactam

Aka: Meropenem Vaborbactam, Vabomere

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II. Indications

  1. See Carbapenem
  2. Meropenem Vaborbactam is indicated in complicated UTI where other options have been exhausted due to Antibiotic Resistance

III. Mechanism

  1. See Carbapenem

IV. Dosing

  1. Standard Adult Dosing
    1. CrCl >=50 ml/min: 4 g IV every 8 hours administered over 3 hours
  2. Renal Dosing
    1. CrCl 30 to 49 ml/min: 2 g IV every 8 hours administered over 3 hours
    2. CrCl 15 to 29 ml/min: 2 g IV every 12 hours administered over 3 hours
    3. CrCl <15 ml/min: 1 g IV every 12 hours administered over 3 hours
      1. Administer after Hemodialysis

V. Drug Interactions

  1. See Carbapenem

VI. Adverse Effects

  1. See Carbapenem
  2. Thrombocytopenia
    1. May oocur with Meropenem (Merrem) in patients with renal dysfunction

VII. Resources

  1. Meropenem Vaborbactam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e237fd0f-3050-42a3-b43e-b6fb4824e93d

VIII. References

  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of CarbapenemAntibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]

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