Definition (NCI)
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A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory. It is a type of biological response modifier.
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Definition (PDQ)
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A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=335280&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=335280&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C33987" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Immunologic Factor
(T129)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
C100416
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SnomedCT |
421559001, 398841009 |
English |
PEG-IFN alfa-2A, PEG-IFN alpha-2A, PEG-interferon alfa-2A, PEGINTERFERON ALFA-2A @ @ UNIDENTIFIED, PEGINTERFERON ALFA-2A UNIDENTIFIED, Peginterferon alpha-2a (substance), Peginterferon alpha-2a, PEG-Interferon Alfa-2a, PEG-IFN alfa-2a, PEG-interferon alfa-2a, polyethylene glycol-interferon alfa-2a, PEG-IFN alpha-2a, PEG-interferon alpha-2a, peginterferon alpha-2a, pegylated interferon alpha-2a, polyethylene glycol-interferon alpha-2a, peginterferon alfa-2a [Chemical/Ingredient], peginterferon alpha-2a (medication), peg-interferon alfa-2a, pegylated interferon alfa-2a, Peginterferon alfa-2a (product), Peginterferon alfa-2a, PEG-IFNA2a, peginterferon alfa-2a, polyethylene glycol-interferon alfa-2A, PEGINTERFERON ALFA-2A, Peginterferon Alfa-2a |
Spanish |
peginterferón alfa-2a (sustancia), peginterferón alfa-2a, cefalea posmielografía (producto), cefalea posmielografía |