III. Contraindications

IV. Mechanism

  1. See Interferon Alfa-2B
  2. Pegylated Interferon is recombinant Interferon alfa conjugated to Polyethylene Glycol (PEG)
    1. PEG component decreases Interferon clearance and extends its therapeutic effects
    2. Pegylated Interferon is typically preferred over the non-pegylated Interferon (e.g. Interferon Alfa-2B)

V. Dosing: Chronic Hepatitis B Infection

  1. Store in refrigerator
  2. Adult
    1. Dose 180 mg SQ in Abdomen or thigh once weekly for 48 weeks
  3. Renal: Decrease dose if eGFR <30 ml/min or Hemodialysis
    1. Dose 135 mcg SQ weekly

VI. Adverse Effects

VII. Safety

  1. Pregnancy Category C
  2. Avoid in Lactation

VIII. Monitoring

Images: Related links to external sites (from Bing)

Related Studies