II. Indications
- Under FDA review in early 2022, emergency approved for age 18 years and older
- Consider in high risk patients over age 18 years (see above, esp. if unvaccinated)
III. Contraindications
- Contraindicated in pregnancy (birth defect risk) and affects mutagenesis in sperm
- Women should use reliable Contraception for at least 4 days after use
- Men should use Condoms for 3 months after use
IV. Mechanism
- Blocks Covid19 replication by inserting into the viral RNA
V. Dosing
- Take 4 capsules twice daily for 5 days (and start within 5 days of onset)
VI. Efficacy
- NNT: 35 unvaccinated patients to prevent one hospitalization (similar to Monoclonal Antibody efficacy)
- Less effective than Paxlovid
VII. Resources
VIII. References
- (2022) Presc Lett 29(1): 1