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Definition (NCI)
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Any beta-lactam antibiotic derived from Pencillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
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Definition (NCI_NCI-GLOSS)
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A drug that is used to treat infection. It belongs to the family of drugs called antibiotics.
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Definition (MSH)
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A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
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Definition (CSP)
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group of natural or semisynthetic antibacterial antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group; they exert a bacteriocidal as well as bacteriostatic effect on susceptible bacteria by interfering with the final stages of the synthesis of cell wall peptidoglycan.
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| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
| MSH |
D010406
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| SnomedCT |
373270004, 6369005 |
| English |
Penicillins, Antibiotics, Penicillin, Penicillin Antibiotics, penicillin (medication), penicillin, Penicillins [Chemical/Ingredient], penicillins, penicillin antibiotic, penicillin antibiotics, BETA-LACTAM ANTIBACTERIALS, PENICILLINS, Penicillin, Penicillin -class of antibiotic- (product), Penicillin -class of antibiotic- (substance), Penicillin -class of antibiotic-, Penicillin Antibiotic |
| Swedish |
Penicilliner
|
| Czech |
peniciliny
|
| Finnish |
Penisilliinit
|
| Russian |
PENITSILLINY, ПЕНИЦИЛЛИНЫ |
| Japanese |
ペニシリン系抗生物質, ペニシリン類, 抗生物質-ペニシリン系, ペニシリン |
| Croatian |
PENICILINI
|
| Polish |
Penicyliny
|
| Spanish |
penicilina (clase de antibiótico) (producto), penicilina (clase de antibiótico) (sustancia), penicilina (clase de antibiótico), Penicilinas, Antibióticos Penicilinos |
| French |
Pénicillines
|
| German |
Antibiotika, Penicillin-, Penicilline |
| Italian |
Penicilline
|
| Portuguese |
Antibióticos Penicilina, Penicilinas |
