Mushroom Poisoning

Aka: Mushroom Poisoning, Cyclopeptide Mushroom, Hepatotoxic Mushroom, Neurotoxic Mushroom, Nephrotoxic Mushroom, Amanita Species Mushroom Poisoning, Toadstool Poisoning, Mycotoxins

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II. Epidemiology

  1. Prepared foods with toxic mushrooms is most common type of lethal exposure

III. Types

  1. Neurotoxic Mushrooms
    1. Amanita muscaria and pantherina (Cholinergic Toxicity)
    2. Inocybe and Clitocybe species (parasympathetic)
    3. Coprinus atramentarius (Antabuse-like Alcohol effect)
    4. Psilcybe (Hallucinogen)
    5. Gyromitra esculenta or false morel: severe Neurotoxin
  2. Hepatotoxic Mushrooms (Cyclopeptide Mushrooms)
    1. Background
      1. Amatoxins (cyclic peptides) are heat stabile with high bioavailability
      2. Amatoxins inhibit RNA polymerase II and suppress protein synthesis
    2. Amanita phalloides (severe hepatotoxicity)
      1. White cap and white gills
      2. Stem ascends from a cup at the base of the mushroom
      3. Stem encircled by a white skirt below the cap
    3. Amanita Virosa
    4. Amanita Verna
    5. Galerina Species
    6. Lepiota Species
  3. Nephrotoxic Mushrooms
    1. Norleucine mushrooms (includes Amanita smithiana)
    2. Orellanine mushrooms

IV. Findings: Hepatotoxic Mushrooms (Cyclopeptide Mushrooms, Amatoxins)

  1. Phase 1: Gastrointestinal (5-24 hours after ingestion)
    1. Diarrhea
    2. Nausea
    3. Vomiting
  2. Phase 2: Liver Injury (12-36 hours after ingestion)
    1. Increased Liver Function Tests
    2. Increased INR
  3. Phase 3: Liver Failure (2-6 days after ingestion)
    1. Hypoglycemia
    2. Jaundice
    3. Renal Failure
    4. Hepatic Encephalopathy and coma

V. Management: Approach

  1. See Unknown Ingestion
  2. Call poison control for any suspected ingestion
    1. Consulting mycologists may be available in some regions if mushroom ingested is brought to ED
  3. Initial general management
    1. Intravenous hydration and Anti-emetics are typically the only management needed
    2. Decontamination if recent ingestion
      1. Oral Activated Charcoal may absorb amatoxins
  4. Symptom presentation may be more accurate than mushroom identification
    1. Vomiting within 1-2 hours of ingesting a single mushroom
      1. Gastrointestinal irritation is more likely
      2. Intravenous hydration and Anti-emetics are typically the only management needed
    2. Vomiting with later onset may suggest Hepatotoxic Mushroom ingestion
      1. See Hepatotoxic Mushroom ingestion
      2. Liver Transaminases (AST, ALT) are typically increased by the onset of gastrointestinal symptoms
  5. Hepatotoxic Mushroom ingestion suspected
    1. Admit all patients
    2. Obtain baseline Liver Function Tests and follow serial levels
    3. First-line management
      1. N-Acetylcysteine
    4. Additional management
      1. High dose Penicillin (Benzylpenicillin) 0.5 to 1.0 MU/kg/day IV
      2. Cimetidine
    5. Other medications used
      1. Silymarin (Milk Thistle extract)
      2. Thioctic Acid
    6. Consider for liver transplant
      1. Indicated in acute toxic fulminant liver failure
  6. Nephrotoxic Mushrooms
    1. Present with Acute Renal Failure starting 2-5 days after ingestion (presentation may be delayed 2 weeks)
    2. May require Dialysis
      1. Renal Function returns in most cases
  7. Hallucinogenic mushooms
    1. Supportive care
    2. Resolves without residua
  8. Cholinergic mushrooms
    1. See Cholinergic Toxicity
    2. Muscarinic effects (Excessive Salivation, eye tearing, Diarrhea)
    3. Typically do not cause nicotinic effects (paralysis or Seizures)

VI. References

  1. Swadron and Nordt in Majoewsky (2013) EM:Rap 13(3):2
  2. Tomaszewski (2021) Crit Dec Emerg Med 35(3):24

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Related Studies

Ontology: Mushroom Poisoning (C0026865)

Definition (MSH) Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.
Concepts Injury or Poisoning (T037)
MSH D009145
SnomedCT 86505009
English Mushroom Poisonings, Poisoning, Mushroom, Poisonings, Mushroom, Mushroom Poisoning, POIS MUSHROOM, MUSHROOM POIS, Mushroom Poisoning [Disease/Finding], poisoning mushroom, mushroom poisoning, Mushroom poisoning, Mycetism, mushrooms; poisoning, mycetismus, poisoning; mushrooms
Swedish Svampförgiftning
Czech houby - otrava
Finnish Sienimyrkytykset
Russian GRIBAMI OTRAVLENIE, ГРИБАМИ ОТРАВЛЕНИЕ
Japanese キノコ中毒, 食中毒-キノコ, 中毒-キノコ, きのこ中毒
Croatian OTROVANJE GLJIVAMA
Polish Zatrucie grzybami
Norwegian Soppforgiftning, Giftig sopp
Spanish Envenenamiento por Setas, Intoxicación por Hongos (Setas), Intoxicación Alimentaria por Setas, Intoxicación por Ingestión de Setas, intoxicación por hongos, intoxicación por ingesta de hongos (trastorno), intoxicación por ingesta de hongos, intoxicación por ingesta de setas, intoxicación por setas, Intoxicación por Setas
Portuguese Envenenamento Alimentar por Cogumelos, Intoxicação por Ingestão de Cogumelos, Envenenamento por Cogumelos, Intoxicação por Cogumelos, Intoxicação Alimentar por Cogumelos
Dutch paddestoelen; vergiftiging, vergiftiging; paddestoelen, Paddenstoelenvergiftiging, Vergiftiging, paddenstoelen-
German Pilzvergiftung
Italian Avvelenamento da funghi
French Intoxication par les champignons, Mycétisme
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Mycotoxins (C0026955)

Definition (NCI) Mycotoxins are toxic, secondary metabolites of low molecular weight produced by naturally occurring fungi. Mycotoxins are neither infectious nor contagious, but can occur on a herd-wide basis.
Definition (MSH) Toxic compounds produced by FUNGI.
Definition (CSP) toxic substance produced by a fungus.
Concepts Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D009183
SnomedCT 44644008
LNC LP19630-0
English Fungal Toxins, Mycotoxins, Toxins, Fungal, mycotoxin, Mycotoxins [Chemical/Ingredient], fungal toxin, mycotoxins, Fungal toxin, Mycotoxin, Mycotoxin (substance), Fungal toxin, NOS, Mycotoxin, NOS, Fungal Toxin
Swedish Mykotoxiner
Czech mykotoxiny
Finnish Mykotoksiinit
Russian GRIBKOVYE TOKSINY, MIKOTOKSINY, ГРИБКОВЫЕ ТОКСИНЫ, МИКОТОКСИНЫ
French Toxines fongiques, Mycotoxines
Polish Mykotoksyny
Japanese 真菌毒, 菌類毒素, マイコトキシン, ミコトキシン
Croatian MIKOTOKSINI
Spanish Toxinas Fúngicas, micotoxina (sustancia), micotoxina, toxina fúngica, Micotoxinas, Toxinas de Hongos
Portuguese Toxinas Fúngicas, Micotoxinas, Toxinas de Fungos
German Mykotoxine, Pilztoxine
Italian Micotossine
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Amanita species poisoning (C0274884)

Concepts Injury or Poisoning (T037)
SnomedCT 42979006
Spanish intoxicación por especie de Amanita (trastorno), intoxicación por especies de Amanita, intoxicación por especie de Amanita, intoxicación por especies de Amanita (trastorno)
English Amanita species poisoning, Amanita species poisoning (disorder)
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Toadstool poisoning (C0858341)

Concepts Injury or Poisoning (T037)
English Toadstool poisoning
Dutch paddestoelvergiftiging
French Intoxication par des champignons
German Pilzvergiftung
Italian Avvelenamento da funghi
Portuguese Intoxicação por cogumelos
Spanish Intoxicación por setas venenosas
Japanese 毒茸中毒, ﾄﾞｸﾀｹﾁｭｳﾄﾞｸ, ﾄﾞｸｷﾉｺﾁｭｳﾄﾞｸ
Czech Otrava muchomůrkou
Hungarian Mérgesgomba mérgezés
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Poisoning and Toxicology

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