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Definition (NCI)
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A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids.
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Definition (NCI_NCI-GLOSS)
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A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.
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Definition (MSH)
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An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
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| Concepts |
Organic Chemical
(T109)
, Vitamin
(T127)
, Pharmacologic Substance
(T121)
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| MSH |
D008063
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| SnomedCT |
70496003
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| English |
Lipoic Acid, Thioctic Acid, 1,2-Dithiolane-3-pentanoic acid, 5-(1,2-Dithiolan-3-yl)pentanoic Acid, Alpha-Lipoic Acid, alpha-lipoic acid, thioctic acid (medication), 6,8-Thioctic Acid, Thioctic Acid [Chemical/Ingredient], acid lipoic, lipoic acid, acid alpha lipoic, acid alpha-lipoic, acids lipoic, ALPHA LIPOIC ACID, Acid, alpha-Lipoic, alpha Lipoic Acid, alpha-Lipoic Acid, Alpha Lipoic Acid, .alpha.-lipoic acid, .ALPHA.-LIPOIC ACID, .alpha.-lipoic Acid, .Alpha.-Lipoic Acid, thioctic acid, .Alpha.-lipoic acid, alpha lipoic acid, Lipoic acid, Lipoic acid (substance), Thioctic acid, alpha-Lipoic acid, ALPHA-LIPOIC ACID |
| Swedish |
Tioktacid
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| Czech |
kyselina lipoová
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| Finnish |
Tioottihappo
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| Russian |
LIPOEVAIA KISLOTA, TIOKTOVAIA KISLOTA, ЛИПОЕВАЯ КИСЛОТА, ТИОКТОВАЯ КИСЛОТА |
| Japanese |
チオクト酸, リポ酸 |
| Spanish |
Ácido Tióctico, ácido alfa - lipoico, ácido lipoico (sustancia), ácido lipoico, ácido tióctico, Ácido Lipoico |
| Portuguese |
Ácido Tióctico, Ácido Lipoico |
| Polish |
Kwas tioktanowy, Kwas liponowy |
| French |
Acide thioctique, Acide alpha-lipoïque, Acide lipoïque |
| Norwegian |
Liponsyre, Lipoicsyre, Alfa-lipoicsyre, Thioctic acid, Tioktsyre, ALA |
| German |
Alpha-Liponsäure, Liponsäure, Thioctansäure, Thioctsäure |
| Italian |
Acido tiottico
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