II. Indications
-
Diabetic Neuropathy
- NOT recommended (low efficacy - see below)
III. Mechanism
- Natural Thiol Supplement
- Synthesized in small amounts within plants and animals (including humans)
- Higher concentration in some foods (organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran)
- Antioxidant properties
- Other functions
- Metal-chelating properties
- Cofactor in several mitochondrial enzymes that decarboxylate alpha-keto acids
IV. Dosing
- Oral: 600 to 1800 mg orally daily
V. Efficacy: Diabetic Neuropathy
- NOT recommended for Diabetic Neuropathy
- Lack of improvement compared with Placebo over 6-24 months (in Cochrane review)
- Low efficacy orally which is its primary use, better efficacy IV
- However, minimal to no adverse effects
- If prescribed despite poor evidence, discontinue after 1 month if ineffective