Cimetidine

Aka: Cimetidine, Tagamet

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II. Indications

  1. Peptic Ulcer Disease
  2. Esophageal Reflux disease
  3. Gastritis
  4. Allergic Reaction (adjunct)
  5. Viral Warts (off label)

III. Mechanism

  1. See H2 Blocker

IV. Dosing

  1. Adult (and age >=12 years)
    1. Bolus Parenteral dosing: 300 mg IV or IM every 6 to 8 hours
    2. Continuous IV Dosing: 37.5 mg/h IV
    3. Oral Dosing: 400-800 mg orally twice daily
  2. Child age <12 years (300 mg/ml oral solution)
    1. Newborns
      1. Dose: 5-10 mg/kg/day divided every 8-12 hours
    2. Infants
      1. Dose: 10-20 mg/kg/day divided every 6-12 hours
    3. Children <12 years old
      1. Dose: 20-40 mg/kg/day divided every 6 hours
  3. Creatinine Clearance <30 ml/min
    1. Give Cimetidine at half dose

V. Efficacy

  1. See H2 Blocker

VI. Adverse Effects

  1. See H2 Blocker
  2. Cimetidine has more Drug Interactions and side effects
  3. Gynecomastia
  4. Sexual Dysfunction (e.g. decreased libido, Erectile Dysfunction)

VII. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

VIII. Drug Interactions

  1. Antacids
    1. Take Cimetidine at least 1-2 hours before or after Antacid medications
  2. Increases serum concentration of other drugs (P450 Inhibitor)
    1. Carbamazepine
    2. Cyclosporine
    3. Diazepam
    4. Labetalol
    5. Lidocaine
    6. Nifedipine
    7. Phenytoin
    8. Procainamide
    9. Propranolol
    10. Quinidine
    11. Theophylline
    12. Tricyclic Antidepressants
    13. Valproic Acid
    14. Warfarin
  3. Decreases absorption of other medications
    1. Ketoconazole
    2. Itraconazole

IX. Resources

  1. Cimetidine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=496e258d-a5fd-42da-9a86-73afc8be359b

X. References

  1. (2012) Presc Lett, 19(7): 38
  2. Baird (2015) Am Fam Physician 92(8): 705-14 [PubMed]

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Cost: Medications

cimetidine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CIMETIDINE 200 MG TABLET Generic $0.32 each
CIMETIDINE 300 MG TABLET Generic $0.32 each
CIMETIDINE 300 MG/5 ML SOLN Generic $0.15 per ml
CIMETIDINE 400 MG TABLET Generic $0.42 each
CIMETIDINE 800 MG TABLET Generic $0.85 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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