II. Indications

  1. Functional Constipation (typically infants)

III. Mechanism: Glycerin (Glycerol)

  1. Glycerol (Glycerin) is a trihydroxyalcohol (1,2,3-trihydroxypropane), an intermediate Carbohydrate in Glucose Metabolism
    1. carbohydrateMetabolism.png
  2. Intravascular Effects
    1. Increases blood osmolality and mobilizes water from tissue into the interstitium and plasma
  3. Diuretic Effect
    1. At the nephron's proximal tubule, Glycerin prevents water reabsorption
    2. Increases urinary excretion of Sodium and water (and decreased Blood Volume)
  4. Laxative Effect (Rectal Suppository)
    1. Hyperosmotic Laxative effect, drawing water into the Rectum
  5. Glycerin commercial use
    1. Solvent
    2. Humectant (maintains moisture, e.g. lotion)
    3. Pharmaceutical vehicle

IV. Pharmacokinetics

  1. Glycerin Suppository stimulates bowel evacuation within 15 to 60 minutes

V. Dosing: Glcerin Suppository

  1. Insert suppository high in the Rectum and retain for at least 15 minutes
  2. Infant to age 2 years
    1. Insert 1/2 pediatric suppository per Rectum once daily as needed
  3. Age 2 to 5 years
    1. Insert 1 pediatric suppository per Rectum once daily as needed
  4. Age 6 years to adult
    1. Insert 1 adult suppository per Rectum once daily as needed

VI. Adverse Effects

  1. Anal or rectal mucosa irritation

VIII. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 94
  2. (2023) Management of Constipation, Presc Lett, #390108

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

glycerin suppository (on 10/18/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
GLYCERIN SUPPOSITORY Generic OTC $0.09 each
glycerin (on 10/18/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
GLYCERIN ADULT SUPPOSITORY Generic OTC $0.09 each

Ontology: Glycerin (C0017861)

Definition (NCI) A trihydroxyalcohol with localized osmotic diuretic and laxative effects. Glycerin elevates the blood plasma osmolality thereby extracting water from tissues into interstitial fluid and plasma. This agent also prevents water reabsorption in the proximal tubule in the kidney leading to an increase in water and sodium excretion and a reduction in blood volume. Administered rectally, glycerin exerts a hyperosmotic laxative effect by attracting water into the rectum, thereby relieving constipation. In addition, glycerin is used as a solvent, humectant and vehicle in various pharmaceutical preparations.
Definition (MSH) A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Definition (CSP) 1,2,3-trihydroxypropane, a key intermediate in glucose metabolism; also serves as the bridge between hydrophobic "tails" and hydrophilic "heads" of many membrane lipids; reagent is used as a water-soluble solvent and lubricant.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Organic Chemical (T109)
MSH D005990
SnomedCT 80582002, 59018003, 387330004, 346459006, 225749008, 259474004, 404833002
LNC LP15619-7, MTHU011557
English 1,2,3-Trihydroxypropane, Glycerine, Glycerol, Glycerin (Obsolete), Glycerol analyte, laxatives glycerin, 1,2,3-propanetriol, glycerin (medication), Glycerol - chemical, Glycerol product, Glycerin, GLYCERIN, Glycerol [Chemical/Ingredient], glycerine, glycerin, glycerol, GLycerin, Glycerol product (product), Glycerin (substance), Glycerol - chemical (substance), Glycerol analyte (substance), Glycerin preparation (product), Glycerin preparation, 1,2,3-Propanetriol, Glycerol (substance), Glycerol (product), Glycerin preparation (substance)
French 1,2,3-Propanetriol, Propane-1,2,3-triol, Glycérine, Glycérol
Swedish Glycerol
Spanish 1,2,3-propanotriol, glicerina, preparado de glicerina, análito de glicerol (sustancia), glicerina (sustancia), análito de glicerol, glicerina (producto), glicerol (sustancia), glicerol, preparado de glicerina (sustancia), glicerol (producto), Glicerina, Glicerol
Czech glycerol, glycerin
Finnish Glyseroli
German Glycerol, Glycerin, Glycerinum, Glyzerin, Glyzerol
Russian GLITSEROL, GLITSERIN, ГЛИЦЕРИН, ГЛИЦЕРОЛ
Japanese グリセリン, グリセロール
Croatian Not Translated[Glycerol]
Polish Propanotriol, Glicerol, Gliceryna
Italian Glicerolo
Portuguese Glicerina, Glicerol

Ontology: Glycerin Rectal Suppository (C1617085)

Concepts Clinical Drug (T200)
English Glycerin Rectal Suppository