Lansoprazole

Aka: Lansoprazole, Prevacid

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II. Indications

  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome

III. Contraindications

  1. Hypersensitivity to Proton Pump Inhibitors
  2. Use with caution in severe liver disease
    1. Limit to maximum dose of 15 mg/day

IV. Dosing: Adults

  1. See Helicobacter Pylori Treatment
  2. Background
    1. Generic, OTC
    2. Take 30 minutes prior to a meal
    3. May open capsule and sprinkle on applesauce, cottage cheese, yogurt or in juices (apple, orange, tomato)
      1. May be given via NG tube
  3. Gastroesophageal Reflux
    1. Take 15 mg orally daily for up to 8 weeks
  4. Erosive Esophagitis
    1. Take 30 mg orally daily for 4 weeks, then 15 mg orally daily for up to 6 months
  5. NSAID-Induced Gastric Ulcer
    1. Take 30 mg orally daily for 8 weeks, then 15 mg orally daily for up to 3 months
  6. Zollinger-Ellison Syndrome
    1. Take 60 mg orally daily

V. Dosing: Children

  1. Delivery
    1. May be compounded into liquid for dosing in infants
    2. May sprinkle opened capsule onto food or into juice
    3. Available in a disintegrating tablet
  2. Weight <10 kg (and age 3-12 months)
    1. Dose: 7.5 mg twice daily or 15 mg daily
    2. Dose: 1 mg/kg/day (0.5 to 1.6 mg/kg)
  3. Weight 10 to 30 kg (age 1 to 11 years)
    1. Dose: 15 mg orally daily for up to 12 weeks
  4. Weight >30 kg (age 12 to 17 years)
    1. Dose: 30 mg orally daily for up to 12 weeks

VI. Pharmacokinetics

  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4
  4. Inhibits CYP3A4

VII. Mechanism

  1. See Proton Pump Inhibitor

VIII. Adverse Effects:

  1. See Proton Pump Inhibitor

IX. Precautions

  1. See Proton Pump Inhibitor

X. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

XI. Efficacy

  1. See Proton Pump Inhibitor
  2. Low efficacy in symptomatic Pediatric GERD age <1 year

XII. Drug Interactions

  1. See Proton Pump Inhibitor
  2. Prevacid decreases drug levels
    1. Theophylline

XIII. Resources

  1. Lansoprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=427cf924-be17-47dc-8f77-115fa2f3fe17

XIV. References

  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]

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Related Studies

Cost: Medications

lansoprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LANSOPRAZOLE DR 15 MG CAPSULE Generic $0.18 each
LANSOPRAZOLE DR 15 MG ODT Generic $3.60 each
LANSOPRAZOLE DR 30 MG CAPSULE Generic $0.10 each
LANSOPRAZOLE DR 30 MG ODT Generic $4.64 each
LANSOPRAZOLE ODT 15 MG TABLET Generic $4.72 each
LANSOPRAZOLE ODT 30 MG TABLET Generic $4.21 each
prevacid (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PREVACID 30 MG SOLUTAB Generic $4.21 each
PREVACID DR 30 MG CAPSULE Generic $0.10 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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