II. Indications

  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome

III. Contraindications

  1. Hypersensitivity to Proton Pump Inhibitors
  2. Use with caution in severe liver disease
    1. Limit to maximum dose of 15 mg/day

IV. Dosing: Adults

  1. See Helicobacter Pylori Treatment
  2. Background
    1. Generic, OTC
    2. Take 30 minutes prior to a meal
    3. May open capsule and sprinkle on applesauce, cottage cheese, yogurt or in juices (apple, orange, tomato)
      1. May be given via NG tube
  3. Gastroesophageal Reflux
    1. Take 15 mg orally daily for up to 8 weeks
  4. Erosive Esophagitis
    1. Take 30 mg orally daily for 4 weeks, then 15 mg orally daily for up to 6 months
  5. NSAID-Induced Gastric Ulcer
    1. Take 30 mg orally daily for 8 weeks, then 15 mg orally daily for up to 3 months
  6. Zollinger-Ellison Syndrome
    1. Take 60 mg orally daily

V. Dosing: Children

  1. Delivery
    1. May be compounded into liquid for dosing in infants
    2. May sprinkle opened capsule onto food or into juice
    3. Available in a disintegrating tablet
  2. Weight <10 kg (and age 3-12 months)
    1. Dose: 7.5 mg twice daily or 15 mg daily
    2. Dose: 1 mg/kg/day (0.5 to 1.6 mg/kg)
  3. Weight 10 to 30 kg (age 1 to 11 years)
    1. Dose: 15 mg orally daily for up to 12 weeks
  4. Weight >30 kg (age 12 to 17 years)
    1. Dose: 30 mg orally daily for up to 12 weeks

VI. Pharmacokinetics

  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4
  4. Inhibits CYP3A4

VII. Mechanism

VIII. Adverse Effects:

IX. Precautions

X. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

XI. Efficacy

  1. See Proton Pump Inhibitor
  2. Low efficacy in symptomatic Pediatric GERD age <1 year

XII. Drug Interactions

  1. See Proton Pump Inhibitor
  2. Prevacid decreases drug levels
    1. Theophylline

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Related Studies

Cost: Medications

lansoprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LANSOPRAZOLE DR 15 MG CAPSULE Generic $0.18 each
LANSOPRAZOLE DR 15 MG ODT Generic $3.60 each
LANSOPRAZOLE DR 30 MG CAPSULE Generic $0.10 each
LANSOPRAZOLE DR 30 MG ODT Generic $4.64 each
LANSOPRAZOLE ODT 15 MG TABLET Generic $4.72 each
LANSOPRAZOLE ODT 30 MG TABLET Generic $4.21 each
prevacid (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PREVACID 30 MG SOLUTAB Generic $4.21 each
PREVACID DR 30 MG CAPSULE Generic $0.10 each

Ontology: lansoprazole (C0050940)

Definition (CHV) a drug used to treat heartburn
Definition (MSH) A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Definition (NCI) A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D064747
SnomedCT 108666007, 386888004
LNC LP171614-3
English lansoprazole (medication), LANSOPRAZOLE, lansoprazole (Prevacid), 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole, Lansoprazoles, Lansoprazole, Lansoprazol, lansoprazole, Lansoprazole [Chemical/Ingredient], Lansoprazole (product), Lansoprazole (substance)
Czech lanzoprazol
French Lansoprazole
German 2-Benzimidazolyl(3-methyl-4-(2,2,2-trifluorethoxy)-2-pyridyl)methylsulfoxid, Lansoprazol
Italian Lansoprazolo
Russian AGOPTON, АГОПТОН, ЛАНСОПРАЗОЛ, LANSOPRAZOL
Spanish lansoprazol (producto), lansoprazol (sustancia), lansoprazol

Ontology: Prevacid (C0286036)

Definition (CHV) brand name of lansoprazole a drug used to treat heartburn
Definition (CHV) brand name of lansoprazole a drug used to treat heartburn
Definition (CHV) brand name of lansoprazole a drug used to treat heartburn
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D064747
English prevacid, ogastro, prevacid [brand name], Abbot Brand of Lansoprazole, Lansoprazole Abbot Brand, Ogastro, TAP Brand of Lansoprazole, Lansoprazole TAP Brand, Prevacid