II. Indications
- Peptic Ulcer Disease
- Gastroesophageal Reflux
- Erosive Esophagitis
- Zollinger-Ellison Syndrome
III. Contraindications
- Hypersensitivity to Proton Pump Inhibitors
- Use with caution in severe liver disease
- Limit to maximum dose of 15 mg/day
IV. Dosing: Adults
- See Helicobacter Pylori Treatment
- Background
-
Gastroesophageal Reflux
- Take 15 mg orally daily for up to 8 weeks
- Erosive Esophagitis
- Take 30 mg orally daily for 4 weeks, then 15 mg orally daily for up to 6 months
-
NSAID-Induced Gastric Ulcer
- Take 30 mg orally daily for 8 weeks, then 15 mg orally daily for up to 3 months
- Zollinger-Ellison Syndrome
- Take 60 mg orally daily
V. Dosing: Children
- Delivery
- May be compounded into liquid for dosing in infants
- May sprinkle opened capsule onto food or into juice
- Available in a disintegrating tablet
- Weight <10 kg (and age 3-12 months)
- Dose: 7.5 mg twice daily or 15 mg daily
- Dose: 1 mg/kg/day (0.5 to 1.6 mg/kg)
- Weight 10 to 30 kg (age 1 to 11 years)
- Dose: 15 mg orally daily for up to 12 weeks
- Weight >30 kg (age 12 to 17 years)
- Dose: 30 mg orally daily for up to 12 weeks
VI. Pharmacokinetics
VII. Mechanism
VIII. Adverse Effects:
IX. Precautions
X. Safety
- Pregnancy Category B
- Unknown safety in Lactation
XI. Efficacy
- See Proton Pump Inhibitor
- Low efficacy in symptomatic Pediatric GERD age <1 year
XII. Drug Interactions
- See Proton Pump Inhibitor
- Prevacid decreases drug levels
XIII. Resources
XIV. References
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Related Studies
lansoprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LANSOPRAZOLE DR 15 MG CAPSULE | Generic | $0.18 each |
LANSOPRAZOLE DR 15 MG ODT | Generic | $3.60 each |
LANSOPRAZOLE DR 30 MG CAPSULE | Generic | $0.10 each |
LANSOPRAZOLE DR 30 MG ODT | Generic | $4.64 each |
LANSOPRAZOLE ODT 15 MG TABLET | Generic | $4.72 each |
LANSOPRAZOLE ODT 30 MG TABLET | Generic | $4.21 each |
prevacid (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
PREVACID 30 MG SOLUTAB | Generic | $4.21 each |
PREVACID DR 30 MG CAPSULE | Generic | $0.10 each |
Ontology: lansoprazole (C0050940)
Definition (CHV) | a drug used to treat heartburn |
Definition (MSH) | A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. |
Definition (NCI) | A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D064747 |
SnomedCT | 108666007, 386888004 |
LNC | LP171614-3 |
English | lansoprazole (medication), LANSOPRAZOLE, lansoprazole (Prevacid), 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole, Lansoprazoles, Lansoprazole, Lansoprazol, lansoprazole, Lansoprazole [Chemical/Ingredient], Lansoprazole (product), Lansoprazole (substance) |
Czech | lanzoprazol |
French | Lansoprazole |
German | 2-Benzimidazolyl(3-methyl-4-(2,2,2-trifluorethoxy)-2-pyridyl)methylsulfoxid, Lansoprazol |
Italian | Lansoprazolo |
Russian | AGOPTON, АГОПТОН, ЛАНСОПРАЗОЛ, LANSOPRAZOL |
Spanish | lansoprazol (producto), lansoprazol (sustancia), lansoprazol |
Ontology: Prevacid (C0286036)
Definition (CHV) | brand name of lansoprazole a drug used to treat heartburn |
Definition (CHV) | brand name of lansoprazole a drug used to treat heartburn |
Definition (CHV) | brand name of lansoprazole a drug used to treat heartburn |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D064747 |
English | prevacid, ogastro, prevacid [brand name], Abbot Brand of Lansoprazole, Lansoprazole Abbot Brand, Ogastro, TAP Brand of Lansoprazole, Lansoprazole TAP Brand, Prevacid |