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Ontology:
Omeprazole
(C0028978)
Definition (MSH)
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A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
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Definition (NCI)
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A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
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Definition (NCI_NCI-GLOSS)
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A drug that inhibits gastric acid secretion.
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Definition (CSP)
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substituted benzimidazole used as a gastric acid secretion inhibitor.
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Definition (PDQ)
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A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D009853
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SnomedCT |
25673006, 387137007 |
LNC |
LP18586-5, MTHU004701 |
English |
Omeprazole, 1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, OMEP, 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole, omeprazole, omeprazole (medication), OMEPRAZOLE, Omeprazole [Chemical/Ingredient], omeprazole product, Omeprazole (product), Omeprazole (substance) |
Swedish |
Omeprazol
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Czech |
omeprazol
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Finnish |
Omepratsoli
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Russian |
OMEPRAZOL, ОМЕПРАЗОЛ |
Croatian |
OMEPRAZOL
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Polish |
Omeprazol
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Japanese |
オメプラゾール, オメプラール |
Spanish |
omeprazol (producto), omeprazol (sustancia), omeprazol, Omeprazol |
French |
Oméprazole
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German |
Omeprazol
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Italian |
Omeprazolo
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Portuguese |
Omeprazol
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Ontology:
lansoprazole
(C0050940)
Definition (CHV)
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a drug used to treat heartburn
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Definition (MSH)
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A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
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Definition (NCI)
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A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D064747
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SnomedCT |
108666007, 386888004 |
LNC |
LP171614-3 |
English |
lansoprazole (medication), LANSOPRAZOLE, lansoprazole (Prevacid), 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole, Lansoprazoles, Lansoprazole, Lansoprazol, lansoprazole, Lansoprazole [Chemical/Ingredient], Lansoprazole (product), Lansoprazole (substance) |
Czech |
lanzoprazol
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French |
Lansoprazole
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German |
2-Benzimidazolyl(3-methyl-4-(2,2,2-trifluorethoxy)-2-pyridyl)methylsulfoxid, Lansoprazol |
Italian |
Lansoprazolo
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Russian |
AGOPTON, АГОПТОН, ЛАНСОПРАЗОЛ, LANSOPRAZOL |
Spanish |
lansoprazol (producto), lansoprazol (sustancia), lansoprazol |
Ontology:
pantoprazole
(C0081876)
Definition (NCI)
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A substituted benzimidazole and proton pump inhibitor with antacid activity. Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulphenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C064276
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SnomedCT |
317317009, 395821003 |
LNC |
LP171628-3 |
English |
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, pantoprazole, pantoprazole (medication), pantoprazole [Chemical/Ingredient], PANTOPRAZOLE, Pantoprazole, Pantoprazole (product), Pantoprazole (substance) |
Spanish |
pantoprazol (producto), pantoprazol (sustancia), pantoprazol |
Ontology:
Prevacid
(C0286036)
Definition (CHV)
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brand name of lansoprazole a drug used to treat heartburn
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Definition (CHV)
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brand name of lansoprazole a drug used to treat heartburn
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Definition (CHV)
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brand name of lansoprazole a drug used to treat heartburn
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D064747
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English |
prevacid, ogastro, prevacid [brand name], Abbot Brand of Lansoprazole, Lansoprazole Abbot Brand, Ogastro, TAP Brand of Lansoprazole, Lansoprazole TAP Brand, Prevacid |
Ontology:
rabeprazole
(C0378482)
Definition (MSH)
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A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
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Definition (NCI)
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An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D064750
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SnomedCT |
421279008, 422225001 |
LNC |
LP171632-5 |
English |
Rabeprazole (product), Rabeprazole (substance), 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole, RABEprazole, 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole, Rabeprazole, rabeprazole, Rabeprazole [Chemical/Ingredient], RABEPRAZOLE |
Spanish |
rabeprazol (producto), rabeprazol, rabeprazol (sustancia) |
Czech |
Rabeprazol
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French |
Rabéprazole
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German |
Rabeprazol, 2-((4-(3-Methoxypropoxy)-3-methyl-2- pyridyl)methylsulfinyl)benzimidazol, Rabeprazolum |
Italian |
Rabeprazolo
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Russian |
PARIET, ПАРИЕТ, DEKSRABEPRAZOL, LY-307640, АЦИФЕКС, ATSIFEKS, РАБЕПРАЗОЛ, E 3810, RABEPRAZOL, ДЕКСРАБЕПРАЗОЛ |
Ontology:
Prilosec
(C0700777)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D009853
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German |
Prilosec
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English |
prilosec, PriLOSEC, Prilosec |
Ontology:
Aciphex
(C0875952)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D064750
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English |
aciphex, AcipHex, Aciphex |
Ontology:
Protonix
(C0876139)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C064276
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English |
Protonix, pantoprazole (Protonix), protonix |
Ontology:
Esomeprazole
(C0937846)
Definition (MSH)
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The S-isomer of omeprazole.
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Definition (MSHCZE)
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S-izomer omeprazolu, neracemická forma inhibitoru protonové pumpy.
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Definition (NCI_NCI-GLOSS)
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A drug that blocks acid from being made in the stomach. It is used to treat acid reflux disease and to prevent certain types of gastrointestinal ulcers. Esomeprazole is being studied in the prevention of esophageal cancer and in the treatment of other conditions, including side effects of chemotherapy. It is a type of anti-ulcer agent.
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Definition (NCI)
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The S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D064098
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SnomedCT |
317331009, 396047003 |
LNC |
LP171396-7 |
English |
esomeprazole (medication), esomeprazole, Esomeprazole, Esomeprazole [Chemical/Ingredient], ESOMEPRAZOLE, Esomeprazole (product), Esomeprazole (substance) |
Czech |
esomeprazol
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French |
Ésoméprazole
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German |
Esomeprazol
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Italian |
Esomeprazolo
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Russian |
ЭЗОМЕПРАЗОЛ, EZOMEPRAZOL |
Spanish |
Not Translated[Esomeprazole], esomeprazol (producto), esomeprazol (sustancia), esomeprazol |
Portuguese |
Not Translated[Esomeprazole]
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Ontology:
Nexium
(C0939400)
Definition (CHV)
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brand name of a drug used to treat heartburn and acid reflux
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Definition (CHV)
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brand name of a drug used to treat heartburn and acid reflux
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Definition (MSH)
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Esomeprazole magnesium trade name.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D064098
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English |
nexium [brand name], nexium, NexIUM, Nexium, AstraZeneca Brand of Esomeprazole Magnesium |
German |
Nexium
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Spanish |
Nexium
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Portuguese |
Nexium
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