II. Indications
- HIV Infection (part of combination therapy)
III. Contraindications
- Moderate to severe hepatic Impairment (Child-Pugh Class B, C)
- May use without dose adjustment in mild hepatic Impairment (Child-Pugh Class A)
IV. Mechanism
V. Efficacy
VI. Dosing
- Take with a meal or light snack (>500 calories, >11 g fat) for best absorption
- Tablets may be dissolved in a small amount of liquid
- Adult
- Take 750 mg orally three times daily OR
- Take 1250 mg orally twice daily
- Child (age >=2 years old)
- Other Protease Inhibitors with better potency in children are recommended instead
- Give 20-30 mg/kg orally three times daily OR
- Give 45-55 mg/kg orally twice daily
VII. Adverse Effects
- Well tolerated
- Diarrhea
VIII. Safety
- Pregnancy Category B
- Avoid in Lactation
IX. Drug Interactions
-
Statins
- Use lowest effective dose for Rosuvastatin
- Limit Atorvastatin to 40 mg max dose
- Pravastatin and Fluvastatin do not significantly interact with Nelfinavir
-
Oral Contraceptives
- Decreased efficacy
-
Antacids
- Avoid with Proton Pump Inhibitor
- Buffered Didanosine should be taken at least 1 hour before or 2 hours after Nelfinavir
X. Resources
Images: Related links to external sites (from Bing)
Related Studies
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D019888 |
English | viracept, Viracept, Agouron Brand of Nelfinavir Mesylate, Roche Brand of Nelfinavir Mesylate |
Ontology: Nelfinavir (C0525005)
Definition (NCI) | A synthetic antiviral agent that selectively binds to and inhibits human immunodeficiency virus (HIV) protease. Nelfinavir has activity against HIV 1 and 2. |
Definition (CSP) | HIV protease inhibitor. |
Definition (MSH) | A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D019888 |
SnomedCT | 108706004, 373445001 |
LNC | LP21313-9, MTHU013848 |
English | Nelfinavir, Nelfinavir [Chemical/Ingredient], NFV, NELFINAVIR, nelfinavir, Nelfinavir (product), Nelfinavir (substance) |
Swedish | Nelfinavir |
Czech | nelfinavir |
Finnish | Nelfinaviiri |
Russian | NEL'FINAVIR, NELFINAVIR, НЕЛФИНАВИР, НЕЛЬФИНАВИР |
Japanese | ネルフィナビル |
Polish | Nelfinawir |
Spanish | nelfinavir (producto), nelfinavir (sustancia), nelfinavir, Nelfinavir |
French | Nelfinavir |
German | Nelfinavir |
Italian | Nelfinavir |
Portuguese | Nelfinavir |