II. Indications
-
HIV Infection (part of combination therapy)
- Treatment-experienced patients
- Limited use in clinical practice
III. Mechanism
IV. Dosing: Enfuvirtide
-
General
- Used in combination with other HIV Antiretrovirals
- Rotate injection sites in the upper arm, anterior thigh and Abdomen
- Avoid reinjecting sites of active cutaneous reaction
- Injection kits include all supplies (90 mg enfuviritide per vial, sterile water, syringes)
- Prepare injection by reconstituting powder in 1.1 ml sterile water diluent
- Let stand until dissolves, up to 45 minutes (do not shake)
- Adult
- Inject 90 mg SQ twice daily
- Child (age 6 to 16 years old)
- Inject 2 mg/kg (max 90 mg) SQ twice daily
V. Adverse Effects
- Injection site pain and reaction (common)
- Eosinophilic Hypersensitivity Reaction (<1%)
- Neutropenia
- Increased risk of Bacterial Pneumonia
VI. Safety
- Avoid in Lactation
- Unknown safety in pregnancy (pregnancy registry exists)