Definition (NCI)
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A nucleoside reverse transcriptase inhibitor analog of adenosine.
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Definition (NCI_NCI-GLOSS)
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A drug used to treat infection caused by viruses.
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Definition (CSP)
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inosine nucleoside analog; antiHIV agent.
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Definition (MSH)
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
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Definition (PDQ)
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A synthetic nucleoside analogue of deoxyadenosine in which the 3' hydroxyl on the ribose moiety is replaced by a hydrogen atom. In vivo, didanosine is converted to the active triphosphate form, which is incorporated into DNA. The absence of the 3' hydroxyl inhibits DNA elongation because phosphodiester bonds cannot be made with the substituted hydrogen. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37814&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37814&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C431" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
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MSH |
D016049
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SnomedCT |
75818008, 19194001, 387105006 |
LNC |
LP21309-7, MTHU013844 |
English |
2',3' Dideoxyinosine, 2',3'-Dideoxyinosine, ddI (Antiviral), Didanosine, Dideoxyinosine, 2'3' dideoxyinosine, Inosine, 2',3'-dideoxy-, Didanosine EC, DIDEOXYINOSINE 002 003, DDI, didanosine (medication), didanosine, DIDANOSINE, Didanosine [Chemical/Ingredient], ddi, 2 3 dideoxyinosine, Dideoxyinosine (product), ddI, Didanosine (product), Didanosine (substance), dideoxyinosine, Dideoxyinosine -RETIRED- |
Swedish |
Didanosin
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Czech |
dideoxyinosin
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Finnish |
Didanosiini
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Russian |
DDI (PROTIVOVIRUSNYI), 2',3'-DIDEZOKSIINOZIN, DIDANOZIN, DIDEZOKSIINOZIN, 2',3'-ДИДЕЗОКСИИНОЗИН, ДДИ (ПРОТИВОВИРУСНЫЙ), ДИДАНОЗИН, ДИДЕЗОКСИИНОЗИН |
Japanese |
ジデオキシイノシン, 2',3'-ジデオキシイノシン, ジダノシン |
Italian |
2',3'-Dideossiinosina, Antivirale del ddI, Dideossiinosina, Didanosina |
German |
DIDESOXYINOSIN 002 003, 2',3'-Didesoxyinosin, DDI (Antiviral), Didanosin, Didesoxyinosin |
Polish |
Dideoksyinozyna, Didanozyna |
Portuguese |
2',3'-Didesoxi-Inosina, Didesoxi-Inosina, ddI (Antiviral), Didanosina |
Spanish |
2',3'-dideoxinosina, didesoxinosina-RETIRADO- (concepto no activo), 2´,3´-didesoxinosina, didesoxinosina-RETIRADO-, didanosina (producto), didanosina (sustancia), didanosina, ddI, 2',3'-Didesoxiinosina, ddI (Antiviral), Didanosina, Didesoxiinosina |
French |
Didéoxyinosine
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