Lopinavir

Aka: Lopinavir, Lopinavir/Ritonavir, Kaletra, LPV, LPV/r

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II. Mechanism

  1. Protease Inhibitor

III. Adverse Effects

  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Pancreatitis
    1. May be life threatening
  3. Prolonged use increases risk of Myocardial Infarction
  4. PR Prolongation
  5. QT Prolongation

IV. Dosing

  1. My be better tolerated when taken with food
  2. Typically used in its boosted form with Ritonavir

V. References

  1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  2. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]

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