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Definition (NCI_NCI-GLOSS)
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A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
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Definition (NCI)
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A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
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Definition (MSH)
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Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
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Definition (CSP)
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1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal.
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Definition (PDQ)
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A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D007654
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| SnomedCT |
326240002, 332902002, 324673001, 387216007, 40232005 |
| LNC |
LP15862-3, MTHU002299 |
| English |
Ketoconazole, Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-, Ketoconazole [gyn], Ketoconazole [infections], Ketoconazole [skin], Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, ketoconazole, Ketoconazole [gynaecological use], Ketoconazole [gynecological use], ketoconazole (medication), KETOCONAZOLE, Ketoconazole [Chemical/Ingredient], Ketoconazole [skin] (product), Ketoconazole [infections] (product), Ketoconazole [gynecological use] (product), Ketoconazole (product), Ketoconazole (substance), KCZ, Ketoconazole [gynecological use] (substance), Ketoconazole [infections] (substance), Ketoconazole [skin] (substance) |
| Swedish |
Ketokonazol
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| Spanish |
ketoconazol [infecciones], ketoconazol (piel), Cetoconazol, cetoconazol (uso dermatológico), ketoconazol [antiinfeccioso], ketoconazol [antiinfeccioso] (producto), ketoconazol (uso dermatológico) (producto), cetoconazol [uso ginecológico], ketoconazol (uso dermatológico), cetoconazol (uso dermatológico) (producto), ketoconazol [uso ginecológico] (producto), ketoconazol [uso ginecológico], cetoconazol [antiinfeccioso], Ketoconazol, cetoconazol (producto), cetoconazol (sustancia), cetoconazol, ketoconazol (piel) (producto), ketoconazol (producto), ketoconazol (sustancia), ketoconazol [infecciones] (producto), ketoconazol |
| Czech |
ketokonazol
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| Finnish |
Ketokonatsoli
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| Russian |
KETOKONAZOL, КЕТОКОНАЗОЛ |
| Japanese |
ケトコナゾール, ニゾラール, ニトラゼン, ケトパミン, プルナ |
| Croatian |
KETOKONAZOL
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| Polish |
Ketokonazol
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| Portuguese |
Cetoconazol, Ketoconazol |
| French |
Kétoconazole
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| German |
Ketoconazol
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| Italian |
Ketoconazolo
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