II. Indications
III. Precautions
- See Long-Acting Beta Agonist
- Use in combination with CorticosteroidInhaler in Asthma
- Unlike Formoterol, cannot be used for Single Maintenance and Reliever Therapy
- Use only maintenance doses listed below (do NOT use as rescue medication)
IV. Dosing: Long-Acting Beta Agonists (LABA)
- Salmeterol (Serevent) Dry Powder Diskus (50 ug/inhale)
- Serevent Inhalation aerosol MDI (21 ug/puff)
V. Dosing: Combination of Long-Acting Beta Agonists with Corticosteroids (ICS, for Asthma, COPD)
- Advair Diskus (Fluticasone/Salmeterol: 100/50, 250/50, 500/50)
- One puff twice daily
- Wixela Inhub (Fluticasone/Salmeterol)
- One puff twice daily
- AirDuo Respiclick (Fluticasone/Salmeterol: 55/14, 113/14, 232/14)
- Dose: One puff twice daily
VI. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VII. Pharmacokinetics
- Onset 20 minutes
- Duration 12 hours
VIII. Drug Interactions
- Strong CYP3A4 Inhibitors (e.g. Ketoconazole)
- Increased Salmeterol levels
- Risk of QTc Prolongation
IX. Resources
- Salmeterol (DailyMed)
- Salmeterol and Fluticasone
X. References
- (2022) Comparison of Asthma Medications, Presc Lett, #381217
- (2022) Inhaled Medications for COPD, Presc Lett, #381116
- (2020) Drugs for COPD, Med Lett Drug Ther 62: 137-44
- (2020) Drugs for Asthma, Med Lett Drug Ther 62: 193-200
- (2013) Presc Lett, 20(8): 43
- (2017) Presc Lett 24(7)
- (2001) Med Clin North Am 43(1104):39-40 [PubMed]
- Wilson (2001) Chest 119:2021-6 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
| serevent (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SEREVENT DISKUS 50 MCG | $6.79 each | |
| advair (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ADVAIR 100-50 DISKUS | Generic | $1.41 each |
| ADVAIR 250-50 DISKUS | Generic | $1.63 each |
| ADVAIR 500-50 DISKUS | Generic | $2.89 each |
| ADVAIR HFA 115-21 MCG INHALER | $32.46 per gram | |
| ADVAIR HFA 230-21 MCG INHALER | $42.69 per gram | |
| ADVAIR HFA 45-21 MCG INHALER | $26.18 per gram | |
| airduo respiclick (on 8/17/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| AIRDUO RESPICLICK 113-14 MCG | Generic | $100.84 each |
Ontology: salmeterol (C0073992)
| Definition (NCI) | A highly selective, long-acting beta-2 adrenergic agonist with bronchodilatory activity. Salmeterol's benzene moiety resembles the structure of catecholamines, and occupies the active site of beta-2 adrenergic receptor, while the long, lipophilic side chain of salmeterol, binds to the so called 'exosite' near the beta-2 adrenergic receptors. The binding at the exosite allows the active portion of the molecule to remain at the receptor site and continually engage and disengage with the receptor, therefore providing a long duration of action. This agent stimulates intracellular adenyl cyclase to catalyze the conversion of adenosine triphosphate to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels result in relaxation of bronchiolar smooth muscle, bronchodilation and increased bronchial airflow. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C057823 |
| SnomedCT | 108605008, 372515005 |
| English | salmeterol, salmeterol (medication), salmeterol [Chemical/Ingredient], SALMETEROL, Salmeterol, Salmeterol product, Salmeterol (product), Salmeterol (substance) |
| Spanish | salmeterol (producto), salmeterol (sustancia), salmeterol |
Ontology: Serevent (C0700491)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C057823 |
| English | Serevent, Glaxo Wellcome brand of salmeterol xinafoate, serevent |
