II. Precautions: CYP2C9 Deficiency related to Warfarin toxicity
- Higher risk for Warfarin toxicity and bleeding complications
- Start with lower doses
- Reaching a steady-state INR on Warfarin requires >3 months
- Voora (2005) Thromb Haemost 93:700-5 [PubMed]
III. Interactions: Metabolized by CYP2C9 (Substrates)
- Cardiopulmonary Drugs
- Carvedilol (Coreg)
- Tolbutamide
- Angiotensin Receptor Blockers (ARBs) affected
- ARBs not affected by Cytochrome P450 System
- Miscellaneous
IV. Interactions: Inhibitor of CYP2C9
- Neuropsychiatric drugs
- Cardiopulmonary Drugs
-
Antibiotics and Antifungals
- Fluconazole (Diflucan)
- Ketoconazole
- Metronidazole (Flagyl)
- Ritonavir
- Trimethoprim-sulfamethoxazole (Septra)
V. Interactions: Inducer of CYP2C9
- Neuropsychiatric drugs
- Antibiotics
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Related Studies
Definition (NCI) | Cytochrome P450 2C9 (490 aa, ~56 kDa) is encoded by the human CYP2C9 gene. This protein is involved in the oxidation of fatty acids, steroids and xenobiotics. |
Concepts | Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) |
MSH | C450260 |
English | cyp2c9, Cytochrome P450 MP-4, Cytochrome P450 PB-1, (R)-Limonene 6-Monooxygenase, EC 1.14.13.48, Cytochrome P450 MP-8, EC 1.14.13.80, (S)-Limonene 7-Monooxygenase, Cytochrome P-450MP, EC 1.14.13.-, EC 1.14.13.49, S-mephenytoin 4-hydroxylase, human, cytochrome P-450 CYP2C10 (human), cytochrome P-450 CYP2C9, human, warfarin-7-hydroxylase, human, cytochrome P-450 CYP2C9 (human), CYP2C9 protein, human, Flavoprotein-Linked Monooxygenase, CYP2C9, P-450MP, P450 MP-4, P450 PB-1, Cytochrome P450 2C9, Cytochrome P450, Family 2, Subfamily C, Polypeptide 9, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 10, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9, Mephenytoin 4-Hydroxylase, Microsomal Monooxygenase, S-Mephenytoin 4-Hydroxylase, Xenobiotic Monooxygenase, CYPIIC9, CYP2C10 protein, human, P-450MP protein, human, P450 MP-4 protein, human, P450 MP-8 protein, human |