II. Class

  1. Rifamycin
    1. Inhibits Bacterial RNA Polymerase

III. Mechanism

  1. Long-acting Rifampin derivative

IV. Indications

V. Contraindications

  1. Children under age 2 years
  2. Latent Tuberculosis with suspected resistance to Isoniazid or Rifampin
  3. HIV patients on Antiretrovirals (due to lower drug levels and risk of resistance)
  4. Unknown safety in pregnancy

VI. Dosing

  1. Tuberculosis
    1. Part of multi-drug regimen; high risk of drug resistance Tb if used alone
    2. Rifapentine 600 mg orally twice weekly for 2 months then once weekly for 4 months
  2. Latent Tuberculosis
    1. See Latent Tuberculosis

VII. Adverse Effects

  1. See Rifampin
  2. Hyperuricemia
  3. Body secretion discoloration (orange to brown)
    1. Discolors urine and Contact Lenses
  4. Hepatotoxicity (uncommon)
  5. Thrombocytopenia
  6. Neutropenia (rare)

VIII. Drug Interactions

  1. See Rifampin
  2. Metabolized by Cytochrome P-450 3A3/4

IX. Monitoring

  1. Baseline Liver Function Tests and clinical evaluations

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Cost: Medications

priftin (on 1/3/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PRIFTIN 150 MG TABLET $4.23 each