Phosphodiesterase Inhibitors in COPD

Aka: Phosphodiesterase Inhibitors in COPD, Phosphodiesterase-4 Inhibitor, PDE4 Inhibitor, Phosphodiesterase-3 Inhibitor, PDE3 Inhibitor

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II. Indications

  1. Severe, refractory COPD with Chronic Bronchitis and frequent exacerbations

III. Mechanism

  1. PDE3 and PDE4 Inhibitors increase lung, intracellular cAMP
  2. Bronchodilates and reduces airway inflammation

IV. Medications

  1. Roflumilast (Daliresp) Tablets
  2. Ensifentrine (Ohtuvayre) nebulized

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Related Studies

Related Topics in Pharmacology

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