II. Background
- Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
- http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
- Although FDA Pregnancy Categories are no longer FDA designated, they are included here
- As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
III. Class B: No risk in controlled animal studies
- Cromolyn Sodium (Intal)
- Ipratropium Bromide (Atrovent)
- Terbutaline (Brethine, Brethaire)
- Montelukast (Singulair) - not in Briggs (1998)
- Nedocromil (Tilade) - not in Briggs (1998)
- Zafirlukast (Accolate) - not in Briggs (1998)
IV. Class C: Small risk in controlled animal studies
- Albuterol (Proventil, Ventolin)
- Beclomethasone (Vanceril, Beclovent)
- Most used Inhaled Corticosteroid in pregnancy
- Budesonide (Pulmicort) - not in Briggs (1998)
- Flunisolide (Aerobid) - not in Briggs (1998)
- Fluticasone (Flovent) - not in Briggs (1998)
- Inhaled Triamcinolone (Azmacort)
- Metaproterenol (Alupent)
- Pirbuterol (Maxair) - not in Briggs (1998)
- Salmeterol (Serevent) - not in Briggs (1998)
- Theophylline
- Zileuton (Zyflo) - not in Briggs (1998)
V. References
- Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
- Larimore (2000) Prim Care 27(1):35-53 [PubMed]