II. Indications: Adjunctive in Asthma and Allergic Rhinitis
III. Medications: Montelukast
- Tablets 10 mg
- Oral granules 4 mg
- May be mixed with other foods (not with liquids) and taken within 15 minutes
- Chewable tablets 4 mg, 5 mg
- Containdicated in Phenylketonuria (contain Phenylalanine)
IV. Dosing
-
Asthma or Allergic Rhinitis
- Adults: 10 mg orally at bedtime
- Child age 6 to 14 years: 5 mg orally at bedtime
- Child age 2-5 years: 4 mg orally at bedtime
- Exercise-Induced Bronchospasm (EIB)
V. Mechanism
- Attenuates bronchoconstriction and inflammation
-
Leukotriene Receptor Antagonist (competitive inhibitor at D4 and E4 receptors)
- Similar to Zafirlukast (Accolate)
- Contrast with Leukotriene Synthesis Inhibitor (Zileuton or Zyflo)
VI. Adverse Effects
- See Leukotriene Receptor Antagonist
- Dyspepsia
- Montelukast is associated with increased risk of Major Depression and Suicide
VII. Efficacy
- See See Leukotriene Receptor Antagonist
VIII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
IX. Drug Interactions
- Montelukast levels decreased by other drugs
X. Resources
XI. References
- (2020) Drugs for Asthma, Med Lett Drug Ther 62: 193-200
- (1996) Med Lett Drugs Ther 38:111-2 [PubMed]
- (2000) Med Lett Drugs Ther 42:22-3 [PubMed]
- Scow (2007) Am Fam Physician 75:65-70 [PubMed]
- Wilson (2001) Chest 119:2021-6 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
| montelukast (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| MONTELUKAST SOD 10 MG TABLET | Generic | $0.06 each |
| MONTELUKAST SOD 4 MG GRANULES | Generic | $0.95 each |
| MONTELUKAST SOD 4 MG TAB CHEW | Generic | $0.09 each |
| MONTELUKAST SOD 5 MG TAB CHEW | Generic | $0.08 each |
| singulair (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SINGULAIR 10 MG TABLET | Generic | $0.06 each |
Ontology: montelukast (C0298130)
| Definition (NCI_NCI-GLOSS) | The active ingredient in a drug used to treat symptoms of asthma, such as trouble breathing, tight chest, wheezing, coughing, and runny nose. Montelukast blocks the action of a substance that causes airways in the lungs to narrow and causes other symptoms of asthma. It is a type of leukotriene receptor antagonist and a type of antiasthmatic agent. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C093875 |
| SnomedCT | 320883008, 108619008, 373734003, 373728005 |
| LNC | LP171622-6 |
| English | montelukast (medication), montelukast, montelukast [Chemical/Ingredient], Montelukast agent, Montelukast (product), Montelukast agent (substance), MONTELUKAST, Montelukast product, Montelukast, Montelukast (substance), Montelukast product (product), Montelukast product (substance) |
| Spanish | montelucast, producto (producto), montelukast (producto), montelucast, producto, agente con montelukast (sustancia), agente con montelukast, montelucast, producto (sustancia), montelukast (sustancia), montelukast |
Ontology: Singulair (C0595724)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C093875 |
| English | Singulair, singulair, Cahill May Roberts brand of montelukast sodium, Merck Frosst brand of montelukast sodium, Merck Sharp & Dohme brand of montelukast sodium, Merck brand of montelukast sodium |
