II. Indications: Adjunctive in Asthma and Allergic Rhinitis

III. Dosing

  1. Avoid at mealtime
    1. Take 1 hour before or 2 hours after meals
  2. Dose
    1. Age >=12 years old: 20 mg orally twice daily
    2. Child 5-11 years old: 10 mg orally twice daily

IV. Mechanism

  1. Attenuates bronchoconstriction and inflammation
  2. Leukotriene Receptor Antagonist (competitive inhibitor at D4 and E4 receptors)
    1. Similar to Montelukast (Singulair)
    2. Contrast with Leukotriene Synthesis Inhibitor (Zileuton or Zyflo)

V. Adverse Effects

  1. See Leukotriene Receptor Antagonist
  2. Nausea
  3. Hepatotoxicity risk

VI. Efficacy

VII. Safety

  1. Pregnancy Category B
  2. Avoid in Lactation

VIII. Drug Interactions

  1. Zafirlukast increases other drug levels, potentiating their action
    1. Warfarin
    2. Theophylline
  2. Other drugs decrease Zafirlukast levels
    1. Erythromycin
    2. Theophylline
  3. Other drugs increase Zafirlukast levels
    1. Aspirin (high dose)

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Related Studies

Cost: Medications

zafirlukast (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ZAFIRLUKAST 10 MG TABLET Generic $0.87 each
ZAFIRLUKAST 20 MG TABLET Generic $0.91 each