II. Indications: Adjunctive in Asthma and Allergic Rhinitis
III. Dosing
- Avoid at mealtime
- Take 1 hour before or 2 hours after meals
- Dose
- Age >=12 years old: 20 mg orally twice daily
- Child 5-11 years old: 10 mg orally twice daily
IV. Mechanism
- Attenuates bronchoconstriction and inflammation
-
Leukotriene Receptor Antagonist (competitive inhibitor at D4 and E4 receptors)
- Similar to Montelukast (Singulair)
- Contrast with Leukotriene Synthesis Inhibitor (Zileuton or Zyflo)
V. Adverse Effects
- See Leukotriene Receptor Antagonist
- Nausea
- Hepatotoxicity risk
VI. Efficacy
- See See Leukotriene Receptor Antagonist
VII. Safety
- Pregnancy Category B
- Avoid in Lactation
VIII. Drug Interactions
- Zafirlukast increases other drug levels, potentiating their action
- Other drugs decrease Zafirlukast levels
- Other drugs increase Zafirlukast levels
- Aspirin (high dose)
IX. Resources
X. References
- (2020) Drugs for Asthma, Med Lett Drug Ther 62: 193-200
- (1996) Med Lett Drugs Ther 38:111-2 [PubMed]
- (2000) Med Lett Drugs Ther 42:22-3 [PubMed]
- Scow (2007) Am Fam Physician 75:65-70 [PubMed]
- Wilson (2001) Chest 119:2021-6 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
| zafirlukast (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ZAFIRLUKAST 10 MG TABLET | Generic | $0.87 each |
| ZAFIRLUKAST 20 MG TABLET | Generic | $0.91 each |