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Definition (NCI)
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A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
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Definition (CSP)
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d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
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Definition (MSH)
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Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D003915
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| SnomedCT |
2016004, 387114001 |
| LNC |
LP16105-6, MTHU004183 |
| English |
d-Methorphan, Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-, METHORPHAN D, DXM, dextromethorphan (medication), Dextromethorphan [Chemical/Ingredient], DEXTROMETHORPHAN, d methorphan, d-methorphan, dextromethorphan, Dextromethmorphan, Dextromethorphan (product), Dextromethorphan (substance), Dextromethorphan |
| Swedish |
Dextrometorfan
|
| Czech |
dextromethorfan
|
| Finnish |
Dekstrometorfaani
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| Russian |
DEKSTROMETORFAN, D-METORFAN, ДЕКСТРОМЕТОРФАН, Д-МЕТОРФАН |
| Japanese |
D-メトルファン, デキストロメトルファン, 臭化水素デキストロメトルファン |
| Italian |
d-Metorfano, Destrometorfano |
| German |
METHORPHAN D, D-Methorphan, Dextromethorphan |
| Spanish |
dextrometorfano (sustancia), dextrometorfán (sustancia), dextrometmorfano, dextrometorfán, dextrometorfano (producto), dextrometorfano, Dextrometorfano, d-Metorfano |
| Polish |
Dekstrometorfan
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| French |
Dextrométhorphane
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| Portuguese |
Dextrometorfano, d-Metorfano |
