Anhidrosis

Aka: Anhidrosis, Absent Sweating, Hypohidrosis, Oligohidrosis, Decreased Sweating, Drug-Induced Anhidrosis

II. Definitions

  1. Anhidrosis
    1. Inability to sweat
  2. Hypohidrosis (Oligohidrosis)
    1. Reduced sweating

III. Causes

  1. Neurologic (central or peripheral)
    1. Cerebrovascular Accident (Hypothalamus, pons, Medulla)
    2. CNS Lesion (Hypothalamus, pons, Medulla, spinal cord)
    3. Degenerative Disorders (e.g. Shy-Drager Syndrome)
    4. Peripheral Neuropathy (e.g. Diabetic Neuropathy, Alcoholic Neuropathy)
    5. Autoimmune Autonomic Neuropathy
    6. Horner Syndrome (symathetic system superior cervical Ganglion lesion with Miosis, Ptosis, anhydrosis)
  2. Medications
    1. Alpha Adrenergic Antagonist (e.g. phentolamine)
    2. Acetylcholine receptor antagonists
      1. See Anticholinergic Medications (e.g. Antihistamines such as Diphenhydramine)
      2. Nicotinic acetylcholine receptor antagonists (Dextromethorphan, Bupropion, Amantadine)
      3. Muscarinic acetylcholine receptor antagonists (Atropine, scopolamine, benztropine, Oxybutynin, Meclizine)
    3. Seizure Medications
      1. Topiramate
      2. Zonisamide (Zonegran)
      3. Carbamazepine
    4. Psychiatric Medications
      1. Tricyclic Antidepressants (e.g. Amitriptyline, Doxepin, Nortriptyline, Imipramine)
      2. Antipsychotics (e.g. Chlorpromazine, Clozapine, Olanzapine, Quetiapine)
    5. Miscellaneous Medications
      1. Clonidine
      2. Quinacrine (Mepacrine)
      3. Opioids (e.g. Oxycodone, Fentanyl, Morphine)
      4. Muscle relaxants (e.g. Cyclobenzaprine, Tizanidine)
  3. Sweat Gland Disorders
    1. Various inherited Sweat Gland disorder (e.g. X-Linked Hypohidrotic ectodermal dysplasia)
    2. Localized Sweat Gland destruction or inflammation (tumors, Radiation Therapy, Sjogren Syndrome)
    3. Sweat Gland obstruction (e.g. Psoriasis, Ichthyosis, Eczematous Dermatitis)

IV. Complications

  1. Heat Illness

V. References

  1. Harper (2020) Anhidrosis, Stat Pearls, accessed 1/3/2021
    1. https://www.ncbi.nlm.nih.gov/books/NBK555988/
  2. Cheshire (2008) Drug Safety 31(2):109-26 [PubMed]

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Related Studies

Ontology: Anhidrosis (C0003028)

Concepts Disease or Syndrome (T047)
MSH D007007
ICD9 705.0
ICD10 L74.4
SnomedCT 14662005, 201189007, 156414006, 39659002
French ANHIDROSE, Anhydrose, Anhidrose
Portuguese ANIDROSE, Anidrose
Spanish ANHIDROSIS, diaforesis, Anhidrosis, anidrosis, anaforesis, anhidrosis (trastorno), anhidrosis, ausencia de sudación, ausencia de sudoración (hallazgo), ausencia de sudoración
German Anhydrosis, Anhidrose, ANHIDROSE, Anhidrosis
Japanese 無汗症, ﾑｶﾝｼｮｳ
English ANHIDROSIS, Absent sweating, anhidrosis, anhidrosis (diagnosis), anhidrosis (physical finding), absent sweating, absence of sweating, anhydrosis, Anhydrosis, Absence of sweating, Absence of sweating (finding), Anhidrosis (disorder), anidrosis, Anhidrosis, Adiaphoresis
Czech Anhidróza, anhidróza
Korean 무한증
Hungarian Anhydrosis, Anhidrózis
Italian Anidrosi
Norwegian Anhidrose
Dutch anhidrose, Anhidrose
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Hypohidrosis (C0020620)

Definition (NCI_CTCAE) A disorder characterized by reduced sweating.
Definition (NCI) Reduced sweating. Causes include burns, dehydration, radiation, and leprosy.
Definition (MSH) Abnormally diminished or absent perspiration. Both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.
Concepts Disease or Syndrome (T047)
MSH D007007
ICD10 L74.4
SnomedCT 201189007, 45004005
English Hypohidrosis, HYPOHIDROSIS, Hyphidrosis, hypohidrosis (physical finding), Hypohidrosis [Disease/Finding], hypohidrosis, Oligohidrosis, Hypohidrosis (disorder), oligohidrosis
Spanish HIPOHIDROSIS, Transpiración insuficiencte, hipohidrosis (trastorno), hipohidrosis, oligohidrosis, Hipohidrosis
German HYPOHIDROSE, Hyphidrosis, Hypohidrose
Swedish Hypohidros
Czech hypohidróza, Hypohidróza
Finnish Hypohidroosi
Russian GIPOGIDROZ, ANGIDROZ, АНГИДРОЗ, ГИПОГИДРОЗ
Italian Traspirazione diminuita, Ipoidrosi
Dutch hyphidrosis, hypohidrose, Hidrose, hypo-, Hypohidrose
Portuguese Hifidrose, HIPOHIDROSE, Hipo-Hidrose, Hipoidrose
French HYPOHIDROSE, Hypohidrose
Japanese 乏汗症, ﾎﾞｳｶﾝｼｮｳ
Polish Pocenie się zmniejszone
Hungarian Hypohidrosis, Hyphidrosis
Norwegian Hypohidrose
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Sweat Gland Disorders

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