II. Indications

III. Dosing: Standard

  1. Adult: 25-50 mg PO/IV/IM q6h
  2. Child: 5 mg/kg/day divided qid (12.5 mg/5 ml)

IV. Preparation: Diphenhydramine 1% (for Local Anesthesia)

  1. Dilute Diphenhydramine 5% in Normal Saline (1:4)
  2. Longer delay to onset of action than Lidocaine
  3. Shorter duration of action than Lidocaine

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Cost: Medications

diphenhydramine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DIPHENHYDRAMINE 12.5 MG/5 ML Generic OTC $0.01 per ml
DIPHENHYDRAMINE 25 MG CAPSULE Generic OTC $0.03 each
DIPHENHYDRAMINE 25 MG TABLET Generic OTC $0.04 each
DIPHENHYDRAMINE 50 MG CAPSULE Generic OTC $0.02 each
DIPHENHYDRAMINE 50 MG/ML VIAL Generic $0.85 per ml