II. Background
- Cost: $20/5g tube
III. Indications
- Severe Aphthous Ulcers
IV. Mechanism: Reduces local inflammation
- Inhibits Histamines
- Inhibits Leukotrienes
V. Efficacy
- Speeds up ulcer healing by 1 day
VI. Dosing
- Apply 1/4 inch oral paste to ulcer after meals and qhs
- Start as soon as symptom onset
- Use until ulcer heals up to 10 days
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Related Studies
| Definition (NCI) | An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C045742 |
| SnomedCT | 108897008, 413507000 |
| English | 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-, amlexanox, amoxanox, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic Acid, 2-Amino-7-(1-methylethyl)-5-oxo-, amlexanox (medication), amlexanox [Chemical/Ingredient], 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic Acid, Amlexanox (substance), Amlexanox, Amlexanox (product), AMLEXANOX |
| Spanish | amlexanox (sustancia), amlexanox, amlexanox (producto) |
Ontology: Aphthasol (C1097532)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C045742 |
| English | Aphthasol, GlaxoSmithKline brand of amlexanox |
