II. Indications: Higher risk of serious Allergic Reaction
- Antitoxin use (risk of Serum Sickness)
- Patients with history of multiple drug sensitivities
III. Preparation
- Discuss risks and benefits with patient
- Be prepared to treat Anaphylaxis
IV. Protocol: Administer prior to suspected medication
- Diphenhydramine (Benadryl) 1 mg/kg up to 50 mg IV
- Cimetidine (Tagamet) 6 mg/kg IV up to 300 mg IV