Acute Generalized Exanthematous Pustulosis

Aka: Acute Generalized Exanthematous Pustulosis, AGEP

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II. Pathophysiology

  1. Adverse Drug Reaction

III. Symptoms

  1. Rash onset within four days of offending medication exposure

IV. Signs

  1. Fever
  2. Rash
    1. Onset at flexor surfaces (e.g. neck, axilla, antecubital fossa, popliteal fossa)
    2. Tiny, non-follicular Pustules

V. Causes

  1. Beta-lactam Antibiotics (Penicillins, Cephalosporins, Carbapenems)
  2. Macrolide Antibiotics (e.g. Erythromycin, Azithromycin)
  3. Calcium Channel Blockers

VI. Labs

  1. Complete Blood Count
    1. Leukocytosis
    2. Neutrophilia

VII. Management

  1. Eliminate the offending agent
  2. Consider Topical Corticosteroids

VIII. References

  1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11

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