C1 Human Esterase Inhibitor

Aka: C1 Human Esterase Inhibitor, C1 Antagonist, C1 Inhibitor, Berinert

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II. Indications

  1. Severe, airway compromising Angioedema
    1. Hereditary Angioedema (treatment of choice)
    2. ACE InhibitorAngioedema (may be effective)

III. Dose

  1. Berinert 20 IU/kg IV for 1 dose
  2. Cost: $3000 per dose

IV. Adverse Effects

  1. Headache (common)
  2. Nausea (common)
  3. Dizziness
  4. Fever
  5. Local skin reaction and Rash
  6. Flu-like symptoms
  7. Hypersensitivity Reaction (uncommon)
  8. Thrombotic event, especially at doses higher than recommended (uncommon)

V. References

  1. (2015) Lexicomp, accessed online 4/9/2015
  2. Farkas (2007) J Allergy Clin Immunol 120(4):941-7 +PMID:17761272 [PubMed]

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Ontology: C1 inhibitor (Human) (C2366367)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH C469952
English C1 INHIBITOR (HUMAN), C1 INHIBITOR, C1 inhibitor (Human), HUMAN C1-ESTERASE INHIBITOR, C1-Esterase Inhibitor, Human, Plasma Protease C1 Inhibitor, C1-Inhibiting Factor, Human C1-Esterase Inhibitor, C1 Inhibitor (Human), C1s inhibitor, human, C1s-INH protein, human, complement C1s inhibitor, human
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Berinert (C2723788)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
English Berinert
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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