C1 Human Esterase Inhibitor

Aka: C1 Human Esterase Inhibitor, C1 Antagonist, C1 Inhibitor, Berinert

II. Indications

  1. Severe, airway compromising Angioedema
    1. Hereditary Angioedema (treatment of choice)
    2. ACE InhibitorAngioedema (may be effective)

III. Dose

  1. Berinert 20 IU/kg IV for 1 dose
  2. Cost: $3000 per dose

IV. Adverse Effects

  1. Headache (common)
  2. Nausea (common)
  3. Dizziness
  4. Fever
  5. Local skin reaction and Rash
  6. Flu-like symptoms
  7. Hypersensitivity Reaction (uncommon)
  8. Thrombotic event, especially at doses higher than recommended (uncommon)

V. References

  1. (2015) Lexicomp, accessed online 4/9/2015
  2. Farkas (2007) J Allergy Clin Immunol 120(4):941-7 +PMID:17761272 [PubMed]

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Related Studies

Ontology: C1 inhibitor (Human) (C2366367)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH C469952
English C1 INHIBITOR (HUMAN), C1 INHIBITOR, C1 inhibitor (Human), HUMAN C1-ESTERASE INHIBITOR, C1-Esterase Inhibitor, Human, Plasma Protease C1 Inhibitor, C1-Inhibiting Factor, Human C1-Esterase Inhibitor, C1 Inhibitor (Human), C1s inhibitor, human, C1s-INH protein, human, complement C1s inhibitor, human
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Berinert (C2723788)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
English Berinert
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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