Clotting Pathway

Aka: Clotting Pathway, Clotting Cascade, Coagulation Pathway, Clotting Factor, Blood Coagulation, Blood Clotting, Clot Formation, Hemostatic Function, Hemostasis, Coagulation Factor, Factor II, Prothrombin, Factor III, Tissue Thromboplastin, Factor V, Factor VII, Factor VIII, Factor IX, Factor X, Factor XI, Factor XII, Factor XIII, Fibrin, Thrombin

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II. Images

  1. Overview
    1. pathClottingCascade.png

III. Physiology: Clotting Factors

  1. Numbered Factors (typically shown with roman numerals)
    1. Factor 1: Fibrinogen
    2. Factor 2: Prothrombin
    3. Factor 3: Tissue Thromboplastin
    4. Factor 4: Calcium
    5. Factor 5: Proaccelerin (Ac Globulin)
    6. Factor 7: Proconvertin
    7. Factor 8: Antihemophilic Factor A (Thromboplastinogen)
    8. Factor 9: Antihemophilic Factor B (Christmas Factor)
    9. Factor 10: Stuart Factor
    10. Factor 11: Antihemophilic Factor C
    11. Factor 12: Hageman Factor
    12. Factor 13: Fibrin Stabilizing Factor
  2. Other factors
    1. Von Willebrand Factor (carries Factor 8)
    2. HMW Kininogen (Fitzgerald Factor)
    3. Prekallikrein (Fletcher Factor)
    4. Platelets
    5. Fibrin
    6. Thrombin

IV. Physiology: Clotting Factor Synthesis

  1. Liver Hepatocytes (decreased synthetic function in Cirrhosis, Acute Hepatic Failure)
    1. Fibrinogen
    2. Prothrombin
    3. Factor 5
    4. Factor 7
    5. Factor 9
    6. Factor 10
    7. Factor 11
    8. Factor 12
    9. Protein C
    10. Protein S
    11. Antithrombin
  2. Liver Sinusoidal Endothelial Cells (levels not related to hepatic synthetic function)
    1. Factor 8
    2. Von Willebrand Factor

V. Physiology: Hemostasis Mechanisms

  1. Vasoconstriction
    1. Chemical and neurologic factors stimulate Vasoconstriction in response to skin and vascular injury
  2. Platelets
    1. Pure Platelet plugs are an initial response to minor injury and may stop minor bleeding without the Clotting Cascade
    2. Platelets also play a major role when combined with the Clotting Cascade
  3. Blood Clots
    1. Triggered Clotting Cascade combines Fibrin with Platelets and other components that adhere to sites of tissue injury

VI. Physiology: Clotting Pathways

  1. Initiators of the Clotting Cascade
    1. Intrinsic Clotting Pathway
      1. Initiated by Negatively charged surface of foreign material or from damaged Red Blood Cells
      2. Pathway is relatively slow (minutes to form blood clot)
        1. Factor XII to Factor XI to Factor IX and Factor VIII which trigger conversion of Factor X to Xa
        2. Factor Xa then proceeds into the common pathway, generating Thrombin and then Fibrin
    2. Extrinsic Clotting Pathway
      1. Initiated by disrupted cell membranes
      2. Damaged cells (including vascular endothelial cells) release Tissue Thromboplastin
      3. Pathway is relatively rapid with Blood Clotting occuring within 15 seconds
        1. Factor VII, Factor V and Calcium combine to trigger conversion of Factor X to Xa
        2. Factor Xa then proceeds into the common pathway, generating Thrombin and then Fibrin
  2. Common Clotting Pathway follows above initiators
    1. Antagonized by Clotting Pathway Inhibition
    2. Prothrombin => Thrombin (catalyzed by Prothrombin activator)
    3. Fibrinogen => Fibrin (catalyzed by Thrombin)
    4. Fibrin combines with Platelets, plasma factors and Red Blood Cells to form blood clot
  3. Factors
    1. Activation
      1. All of these Clotting Factors (both pro-coagulant and Anticoagulant) are Vitamin K Dependent
      2. Vitamin K is required for carboxylation of terminal ends of coagulation Proteins
      3. Without carboxylation, Clotting Factors/Proteins are not activated and Clotting Cascade does not occur
      4. Warfarin inhibits the cyclic interconversion of Vitamin K to a reduced form
        1. Keeps Vitamin K and dependent factors inactive
    2. Procoagulant Factors (Mnemonic: "1972")
      1. Factor 10 (half life 36 hours)
      2. Factor 9 (half life 24 hours)
      3. Factor 7 (half life 7 hours)
      4. Factor 2 (half life 50 hours)
    3. Anticoagulant Factors
      1. Protein C (half life 8 hours)
      2. Protein S (half life 30 hours)

VII. Labs

  1. Background: Blood collection
    1. Glass Blood Collection Tubes will trigger the Intrinsic Clotting Pathway
      1. Glass Blood Collection Tubes therefore contain Anticoagulants to prevent Blood Clotting
    2. Calcium (Factor 4) is a Cofactor in both the extrinsic and intrinsic pathways
      1. Some glass collection tubes contain Calcium binders (e.g. oxalate, citrate) to prevent clotting
  2. Partial Thromboplastin Time (PTT)
    1. Measures intrinsic pathway
    2. Prolonged by
      1. Factor VIII Deficiency (Hemophilia A)
      2. Factor IX Deficiency (Hemophilia B)
  3. Prothrombin Time (PT)
    1. Measures extrinsic pathway
  4. Affecting both ProTime and Partial Thromboplastin Time
    1. Factor X
    2. Factor V
    3. Prothrombin
    4. Fibrinogen
  5. Thrombin Time
    1. Measures only common pathway

VIII. Causes: Coagulation Disorder etiologies

  1. Hypercoagulable State
    1. Protein C Deficiency
    2. Protein S Deficiency
    3. Antithrombin III deficiency
  2. Bleeding Diathesis
    1. Factor VIII Deficiency (Hemophilia A)
    2. Factor IX Deficiency (Hemophilia B)
    3. Von Willebrand's Disease
  3. Medication Induced
    1. Warfarin (Coumadin)
    2. Heparin

IX. Associated Conditions

  1. See Bleeding Disorder
  2. See Thrombophilia (Hypercoagulability)

X. Resources

  1. Coagulation (Wikipedia)
    1. https://en.wikipedia.org/wiki/Coagulation

XI. References

  1. Goldberg (2014) Clinical Physiology, Medmasters, Miami, p. 61-5
  2. Palta (2014) Indian J Anaesth 58(5): 515-23 +PMID: 25535411 [PubMed]
  3. Smith (2015) Crit Rev Biochem Mol Biol 50(4): 326-36 +PMID:26018600 [PubMed]

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Related Studies

Ontology: Blood coagulation (C0005778)

Definition (ICF) Functions related to the coagulation of blood, such as at a site of injury.
Definition (ICF-CY) Functions related to the coagulation of blood, such as at a site of injury.
Definition (GO) The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [http://www.graylab.ac.uk/omd/, ISBN:0198506732]
Definition (NCI) Any of the sequential processes by which coagulation factors interact to form a fibrin clot.
Definition (MSH) The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Definition (CSP) process of the interaction of blood coagulation factors that results in an insoluble fibrin clot.
Definition (NOC) Extent to which blood clots within normal period of time
Concepts Organ or Tissue Function (T042)
MSH D001777
SnomedCT 74848003
LNC LP20917-8
English Blood Coagulation, Coagulation, Blood, Blood Clotting, Blood Clottings, Clotting, Blood, blood coagulation, BLOOD COAG, COAG BLOOD, Clotting functions, blood clotting, blood coagulations, Coagulation, Clotting, Blood--Coagulation, Blood clotting, Blood coagulation, Coagulation (Blood), Coagulation Process, Coagulation-Related Process
Dutch stolling, Bloedstolling, Stolling, bloed-
French Coagulation, Coagulation du sang, Coagulation sanguine
Italian Coagulazione, Coagulazione del sangue
Portuguese Coagulação, Coagulação Sanguínea
Spanish Coagulación, coagulación sanguínea, Coagulación Sanguínea
Swedish Blodkoagulation
Finnish Hyytymisjärjestelmä
Russian SVERTYVANIE KROVI, KROVI SVERTYVANIE, КРОВИ СВЕРТЫВАНИЕ, СВЕРТЫВАНИЕ КРОВИ
Czech Srážení krve, krev - srážlivost, srážlivost krve, krev - koagulace, koagulace krve
Croatian KRV, KOAGULACIJA
Polish Krzepnięcie krwi
Hungarian Alvadás
Japanese 凝血, 血液凝固
Norwegian Blodlevring, Blodkoagulasjon
German Blut-Koagulation, Blutgerinnung
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Blood Coagulation Factor (C0005789)

Definition (NCI) Factors in the blood that are essential for blood coagulation. The absence or mutation of these factors can lead to hemophilia and blood clotting disorders.
Definition (MSH) Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Definition (CSP) class of endogenous substances, usually proteins, that are involved in the blood coagulation process.
Concepts Biologically Active Substance (T123) , Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH D001779
SnomedCT 32877006, 350475008
LNC LP31623-9, LP32810-1
English Blood Coagulation Factor, Blood Coagulation Factors, Coagulation Factor, Blood, Coagulation Factors, Coagulation Factors, Blood, Factor, Blood Coagulation, Factor, Coagulation, Factors, Blood Coagulation, Factors, Coagulation, Coagulation Factor, Blood coagulation factor, COAG FACTORS, BLOOD COAG FACTOR, COAG FACTOR, COAG FACTORS BLOOD, BLOOD COAG FACTORS, FACTORS COAG, FACTOR COAG, COAG FACTOR BLOOD, Blood Coagulation Factors [Chemical/Ingredient], Clotting factors, factors coagulation, blood clotting factors, clotting factor, blood clot factor, blood clots factors, blood coagulation factors, clot factors, blood clotting factor, clot factor, coagulation factor, blood coagulation factor, clotting factors, coagulation factors, Blood coagulation factors, Coagulation factor, Coagulation factor (substance), Blood clotting factor, Blood clotting factor (product), Coagulation factor, NOS, Blood clotting factor (substance), Clotting Factor
French Facteurs de la coagulation sanguine, Facteurs de la coagulation, Facteurs de la coagulation du sang, Facteurs de coagulation
Swedish Blodkoagulationsfaktorer
Czech faktory krevní koagulace
Finnish Hyytymistekijät
Russian SVERTYVANIIA KROVI FAKTORY, FAKTORY SVERTYVANIIA KROVI, СВЕРТЫВАНИЯ КРОВИ ФАКТОРЫ, ФАКТОРЫ СВЕРТЫВАНИЯ КРОВИ
Italian Fattore di coagulazione del sangue, Fattore di coagulazione, Fattori di coagulazione, Fattori di coagulazione del sangue
Croatian KRV, KOAGULACIJSKI FAKTORI
Polish Czynniki krzepnięcia krwi
Japanese 凝固因子, 血液凝固因子
Norwegian Not Translated[Blood Coagulation Factors]
Spanish factor de la coagulación de la sangre (sustancia), factor de coagulación, factor de la coagulación de la sangre, factor de la coagulación sanguínea (producto), factor de la coagulación sanguínea, Factores de Coagulación Sanguínea, Factores de Coagulación
German Blutgerinnungsfaktoren, Gerinnungsfaktoren
Portuguese Fatores de Coagulação, Fatores de Coagulação Sanguínea
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: factor IX (C0015491)

Definition (NCI) Factor IX is a vitamin k-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of ca(2+) ions, phospholipids, and factor VIIIa.
Definition (MSH) Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005164
SnomedCT 54144004, 54378000
LNC LP15961-3, LP32759-0, LP21289-1, LP32814-3, LP32026-4
English Autoprothrombin II, Christmas Factor, Factor IX, Plasma Thromboplastin Component, PTC, Blood-coagulation factor IX, Complex, Factor IX, Factor IX Complex, Factor IX Fraction, Fraction, Factor IX, IX Complex, Factor, IX Fraction, Factor, Blood Coagulation Factor IX, Coagulation Factor IX, Factor IX, Coagulation, IX, Coagulation Factor, factor IX complex, COAGULATION FACTOR VIIII, COAG FACTOR IX, FACTOR VIIII, BLOOD COAG FACTOR IX, Factor IX complex agent, antihemophilic factor B, autoprothrombin II, thromboplastinogen B, Factor IX [Chemical/Ingredient], IX, factor ix, coagulation factor ix, ptc, christmas factor, Coagulation Factor IX Complex Human, factor IX, coagulation factor IX, factor ix complex, Blood coagulation factor IX, FACTOR IX COMPLEX, Coagulation factor IX, Antihemophilic factor B, Christmas factor, Factor IX complex preparation, Factor IX preparation, Plasma thromboplastin component, Platelet cofactor II, Coagulation factor IX (substance), Factor IX complex agent (substance), Antihaemophilic factor B, Factor IX agent, Factor IX complex preparation (substance), EC 3.4.21.22, F9
French Facteur IX de la coagulation, Facteur IX de la coagulation sanguine, PTC (Plasma thromboplastin component), Autoprothrombine II, Facteur IX, Facteur antihémophilique B, Auto-prothrombine II, Facteur anti-hémophilique B, Facteur christmas
Swedish Faktor IX
Czech faktor IX, Christmasův faktor
Finnish Plasman tromboplastiinikomponentti
Italian Componente tromboplastinico plasmatico, PTC, Autoprotrombina II, Fattore IX di coagulazione del sangue, Frazione del fattore IX, Fattore IX di coagulazione, Complesso di fattore IX, Fattore Christmas, Fattore IX
Russian FAKTOR IX, GEMOGLOBIN ANTIGEMOFIL'NYI B, KRISTMAS-FAKTOR, PLAZMENNYI KOMPONENT TROMBOPLASTINA, ГЕМОГЛОБИН АНТИГЕМОФИЛЬНЫЙ B, КРИСТМАС-ФАКТОР, ПЛАЗМЕННЫЙ КОМПОНЕНТ ТРОМБОПЛАСТИНА, ФАКТОР IX
Spanish preparado de factor IX, complejo de factor IX (sustancia), preparado de complejo de factor IX (sustancia), complejo de factor IX, preparado de complejo de factor IX, autoprotrombina II, cofactor II de las plaquetas, componente de tromboplastina del plasma, factor Christmas, factor IX de la coagulación (sustancia), factor IX de la coagulación, factor antihemofílico B, PTC, Autoprotrombina II, Componente de Tromboplastina Plasmica, Factor de Christmas, Factor IX, Factor IX de Coagulación
German KOAGULATIONSFAKTOR VIIII, FAKTOR VIIII, Autoprothrombin II, Christmas-Faktor, Faktor IX, Koagulationsfaktor IX, PTC, Plasmathromboplastinkomponente
Croatian KRV, KOAGULACIJA, FAKTOR IX, FAKTOR IX, KOAGULACIJSKI FAKTOR IX
Polish Czynnik IX, Globulina przeciwkrwawiączkowa B
Japanese IX因子, 血液凝固第IX因子, Christmas因子, オートプロトロンビン2, クリスマス因子, プラスマトロンボプラスチン成分, 抗血友病因子B, 血小板補因子2, 血液凝固9因子, 血液凝固第9因子, 血漿トロンボプラスチン成分, オートプロトロンビンII, 第IX因子
Portuguese Fator IX de Coagulação, PTC, Autoprotrombina II, Componente Plasmático da Tromboplastina, Fator de Christmas, Fator de Coagulação IX, Fator IX
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Factor V (C0015498)

Definition (CHV) a factor in the clotting of blood
Definition (CHV) a factor in the clotting of blood
Definition (CHV) a factor in the clotting of blood
Definition (CHV) a factor in the clotting of blood
Definition (NCI) Coagulation factor V (2224 aa, ~252 kDa) is encoded by the human F5 gene. This protein plays a role in the coagulation cascade.
Definition (MSH) Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Definition (CSP) heat and storage labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex); deficiency of factor V leads to Owrens disease.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005165
SnomedCT 60208008
LNC LP21286-7, LP15964-7
English AC Globulin, Factor Pi, Proaccelerin, coagulation factor V, Blood-coagulation factor V, Blood Coagulation Factor V, Coagulation Factor V, Factor V, Coagulation, V, Coagulation Factor, BLOOD COAG FACTOR V, COAG FACTOR V, AC globulin, labile factor, Factor V [Chemical/Ingredient], proaccelerin, coagulation factor v, factor v, Proaccelerin, Labile Factor, Activated Protein C Cofactor, labile component, Coagulation factor V, Labile factor, Ac globulin, Coagulation factor V (substance), Factor V
French Facteur V de la coagulation, Facteur V de la coagulation sanguine, AC-globuline, Facteur V, Proaccélérine
Swedish Faktor V
Czech faktor V, proakcelerin
Finnish Proakseleriini
Russian PROAKTSELERIN, KOAGULIATSII FAKTOR V, FAKTOR V, КОАГУЛЯЦИИ ФАКТОР V, ПРОАКЦЕЛЕРИН, ФАКТОР V
Italian Proaccelerina, Fattore Pi, AC globulina, Fattore V di coagulazione, Fattore V di coagulazione del sangue, Fattore V
Croatian KOAGULACIJSKI FAKTOR V, FAKTOR V
Polish Czynnik V, Proakceleryna
Japanese AC-グロブリン, 血液凝固第V因子, プラズマプロトロンビン転化因子, プロアクセレリン, 不安定因子, 促進グロブリン, 血液凝固5因子, 血液凝固第5因子, V因子, 第V因子
Portuguese Fator V de Coagulação, Fator de Coagulação V, Fator V, Proacelerina
Spanish factor V de la coagulación (sustancia), factor V de la coagulación, factor lábil, globulina Ac, globulina aceleradora, proacelerina, Factor V, Proacelerina, Factor V de Coagulación
German Ac-Globulin, Faktor V, Koagulationsfaktor V, Labiler Faktor, Proakzelerin
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: factor VII (C0015502)

Definition (NCI) A clotting factor found in the serum. It combines with tissue factor (factor III) to activate factor X in the clotting pathway.
Definition (MSH) Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005167
SnomedCT 30804005
LNC LP19291-1, LP28560-8, LP15966-2
English Factor VII, Factor, Stable, Proconvertin, Stable Factor, Blood-coagulation factor VII, Blood Coagulation Factor VII, Coagulation Factor VII, Factor VII, Coagulation, VII, Coagulation Factor, COAG FACTOR VII, BLOOD COAG FACTOR VII, autoprothrombin I, cothromboplastin, stable factor, proconvertin, Factor VII [Chemical/Ingredient], factor vii, coagulation factor vii, factor vii coagulation, coagulation factor VII, factor VII, Coagulation factor VII, Autoprothrombin I, Stable factor, SPCA, Coagulation factor VII (substance), EC 3.4.21.21, F7, Serum Prothrombin Conversion Accelerator
French Facteur VII de la coagulation sanguine, Facteur VII de la coagulation, Proconvertine, Facteur VII
Swedish Faktor VII
Czech faktor VII, prokonvertin
Spanish factor VII, autoprotrombina I, factor VII de la coagulación (sustancia), factor VII de la coagulación, factor estable, proconvertina, Factor Estable, Factor VII, Proconvertina, Factor VII de Coagulación
Finnish Prokonvertiini
Russian STABIL'NYI FAKTOR, KONVERTIN, KOAGULIATSII FAKTOR VII, FAKTOR VII, ANTIFIBRINOLIZIN, PROKONVERTIN, АНТИФИБРИНОЛИЗИН, КОАГУЛЯЦИИ ФАКТОР VII, КОНВЕРТИН, ПРОКОНВЕРТИН, СТАБИЛЬНЫЙ ФАКТОР, ФАКТОР VII
Italian Fattore di stabilità, Fattore VII di coagulazione del sangue, Proconvertina, Fattore VII
Croatian PROKONVERTIN, KOAGULACIJSKI FAKTOR VII, FAKTOR VII
Polish Prokonwertyna, Czynnik VII
Japanese 安定因子, 血液凝固第VII因子, オートトロンビン1, プラズマプロトロンビン転化促進因子, プロコンバーチン, プロコンベルチン, 血液凝固7因子, 血液凝固第7因子, 血清プロトロンビン転化促進因子, VII因子, 第VII因子, 血液凝固VIIa因子
Portuguese Fator VII de Coagulação, Fator de Coagulação VII, Fator Estável, Fator VII, Proconvertina
German Faktor VII, Koagulationsfaktor VII, Prokonvertin, Stabiler Faktor
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Factor VIII (C0015506)

Definition (NCI) Human coagulation factor-VIII (2351 aa, 267 kDa precursor) is encoded by human factor eight (F8) gene. The protein is an extracellular anti-hemophilic factor that is part of the von Willebrand factor complex. The protein plays a role in the blood coagulation pathway.
Definition (MSH) Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Definition (CSP) antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; produced in the liver and acts in the intrinsic pathway of blood coagulation; serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005169
SnomedCT 89165002, 278910002, 416523005
LNC LP29050-9, LP14587-7, LP14702-2, MTHU009422
English Factor VIII, Thromboplastinogen, Blood-coagulation factor VIII, complex, Blood Coagulation Factor VIII, Coagulation Factor VIII, Antihaemophilic Globulin, Antihemophilic Factor VIII, antihemophilic factor, COAG FACTOR VIII, BLOOD COAG FACTOR VIII, antihemophilic factor A, thromboplastinogen A, platelet cofactor I, hematological agents antihemophilic factors, antihemophilic factors, antihemophilic factors (medication), Blood clotting factor VIII, FACTOR VIII, Factor VIII [Chemical/Ingredient], antihemophilic globulin, blood clotting factor VIII, antihemophilic factor (AHF), antihemophilic factor viii, antihemophilic globulin (AHG), ahf, ahg, factor viii, coagulation factor VIII, Coagulation factor VIII (substance), Factor viii (antihemophilic factor, human) per i.u., Blood coagulation factor VIII, AHF, AHG, Antihemophilic factor, Antihemophilic factor A, Antihemophilic globulin, Coagulation factor VIII, Platelet cofactor I, Antihaemophilic factor, Factor VIII (substance), Antihaemophilic factor A, Antihaemophilic globulin, Factor viii, Coagulation factor VIII (substance) [Ambiguous], Coagulation Factor VIIIc, F8, Factor VIII F8B, Antihaemophilic Factor, Procoagulant Component, Factor VIII product (product), Factor VIII product, ANTIHEMOPHILIC FACTOR
French Facteur VIII de la coagulation sanguine, Facteur VIII de la coagulation, Facteur anti-hémophilique A, Facteur VIII, Facteur antihémophilique A, Thromboplastinogène
Swedish Faktor VIII
Czech faktor VIII
Finnish Antihemofiliaglobuliini
Italian Fattore VIII di coagulazione, Fattore antiemofiliaco, Fattore VIII di coagulazione del sangue, Tromboplastinogeno, Fattore VIII
Russian KOAGULIATSII FAKTOR VIII, FAKTOR VIII, ANTIGEMOFILICHESKII FAKTOR, GLOBULIN ANTIGEMOFIL'NYI, TROMBOPLASTINOGEN, АНТИГЕМОФИЛИЧЕСКИЙ ФАКТОР, ГЛОБУЛИН АНТИГЕМОФИЛЬНЫЙ, КОАГУЛЯЦИИ ФАКТОР VIII, ТРОМБОПЛАСТИНОГЕН, ФАКТОР VIII
Japanese 抗血友病因子〔A〕, 抗血友病性因子, トロンボプラスチノゲン, 凝固第8因子凝固抗原, 抗血友病グロブリン, 抗血友病性グロブリン, 第VIII因子, 血液凝固第8因子, プラズマトロンボプラスチン因子, 血小板補因子1, 血液凝固8因子, 前凝固活性第8因子, トロンボプラスチノーゲン, VIII因子, 血液凝固第VIII因子
Spanish producto con factor VIII (producto), factor VIII (producto), factor VIII, producto con factor VIII, globulina antihemofílica, factor VIIIc de la coagulación, factor VIII de la coagulación (sustancia), cofactor I de las plaquetas, factor antihemofílico A, factor VIII de la coagulación, factor VIII de la coagulación (concepto no activo), factor antihemofílico, factor de coagulación VIII (sustancia), factor de coagulación VIII, Factor VIII, Factor VIII de Coagulación, Tromboplastinógeno
Croatian KOAGULACIJSKI FAKTOR VIII, FAKTOR VIII, KRV, KOAGULACIJA, FAKTOR VIII, ANTIHEMOFILIJSKI FAKTOR
Polish Czynnik VIII, Globulina antyhemofilowa
Portuguese Fator VIII de Coagulação, Fator de Coagulação VIII, Fator VIII, Tromboplastinogênio
German Faktor VIII, Koagulationsfaktor VIII, Thromboplastinogen, Antihämophiler Faktor
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: factor X (C0015518)

Definition (NCI) Coagulation factor X (488 aa, 55 kDa) is encoded by the human F10 gene. This protein is involved in proteolysis and blood coagulation.
Definition (MSH) Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D005170
SnomedCT 81444003
LNC LP70314-7, LP21290-9, LP15973-8
English Autoprothrombin III, Factor X, Stuart Factor, Stuart Prower Factor, Stuart-Prower Factor, Stuart factor, coagulation factor X, Blood-coagulation factor X, Blood Coagulation Factor X, Coagulation Factor X, Factor X, Coagulation, X, Coagulation Factor, COAG FACTOR X, BLOOD COAG FACTOR X, autoprothrombin III, Prower factor, EC 3.4.21.6, Prothrombinase, Factor X [Chemical/Ingredient], coagulation factor x, factor x, factor x blood coagulation, factor prower stuart, stuart-prower factor, stuart factor, factor X, Coagulation factor X, Stuart-Prower factor, Coagulation factor X (substance)
French Facteur X de la coagulation sanguine, Facteur X de la coagulation, Facteur Stuart, Facteur X, Autoprothrombine III, Facteur Stuart-Prower, Facteur de Stuart-Prower, Facteur Prower
Swedish Faktor X
Czech faktor X
Finnish Stuart Poerin tekijä
Russian FAKTOR X, KOAGULIATSII FAKTOR X, PRAUER-FAKTOR, STIUART-PRAUER-FAKTOR, AUTOPROTROMBIN III, STIUARTA FAKTOR, АУТОПРОТРОМБИН III, КОАГУЛЯЦИИ ФАКТОР X, ПРАУЭР-ФАКТОР, СТЮАРТА ФАКТОР, СТЮАРТ-ПРАУЭР-ФАКТОР, ФАКТОР X
Japanese スチュワート･プロワー因子, 血液凝固第X因子, オートプロトロンビンIII, オートプロトロンビン3, スチュアート-プラウァー因子, スチュアート因子, スチュワート因子, 血液凝固10因子, 血液凝固第10因子, スチュワート-プロワー因子
Italian Fattore di Stuart-Prower, Fattore X della coagulazione, Fattore di Stuart, Autoprothrombin III, Fattore X della coagulazione del sangue, Fattore di Stuart Prower, Fattore X
Croatian FAKTOR X, KRV, KOAGULACIJA, FAKTOR X, KOAGULACIJSKI FAKTOR X
Polish Czynnik X, Czynnik Stuarta-Prowera
Portuguese Fator X de Coagulação, Autoprotrombina III, Fator de Coagulação X, Fator de Stuart, Fator de Stuart-Prower, Fator X
Spanish autoprotrombina III, factor Stuart - Prower, factor X de la coagulación (sustancia), factor X de la coagulación, Autoprotrombina III, Factor de Stuart-Prower, Factor de Stuart, Factor X, Factor X de Coagulación
German Autoprothrombin III, Autothrombin III, Faktor X, Koagulationsfaktor X, Stuart-Faktor, Stuart-Power-Faktor
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Factor XI (C0015522)

Definition (MSH) Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005172
SnomedCT 46572007
LNC LP15977-9, LP21291-7
English Antecedent, Plasma Thromboplastin, Factor XI, Plasma Thromboplastin Antecedent, Thromboplastin Antecedent, Plasma, coagulation factor XI, Blood-coagulation factor XI, Blood Coagulation Factor XI, Coagulation Factor XI, Factor XI, Coagulation, XI, Coagulation Factor, BLOOD COAG FACTOR XI, COAG FACTOR XI, antihemophilic factor C, Factor XI [Chemical/Ingredient], plasma thromboplastin antecedent, factor xi, pta, coagulation factor xi, Antihemophilic factor C, Coagulation factor XI, PTA, Plasma thromboplastin antecedent, Coagulation factor XI (substance), Antihaemophilic factor C
French Facteur XI de la coagulation, Facteur XI de la coagulation sanguine, PTA (Plasma Thromboplastin Antecedent), Facteur de Rosenthal, Facteur Rosenthal, Facteur prothromboplastique C, Facteur XI
Swedish Faktor XI
Czech faktor XI
Finnish Hyytymistekijä XI
Russian KOAGULIATSII FAKTOR XI, FAKTOR XI, PLAZMENNYI PREDSHESTVENNIK TROMBOPLASTINA, PPT, КОАГУЛЯЦИИ ФАКТОР XI, ПЛАЗМЕННЫЙ ПРЕДШЕСТВЕННИК ТРОМБОПЛАСТИНА, ППТ, ФАКТОР XI
Italian Fattore XI della coagulazione, Plasma tromboplastina antecedente, Fattore XI della coagulazione del sangue, Fattore XI
Croatian KRV, KOAGULACIJA, FAKTOR XI, FAKTOR XI, KOAGULACIJSKI FAKTOR XI
Polish Czynnik XI
Japanese 血液凝固第XI因子, 血漿トロンボプラスチン前駆因子, プラズマトロンボプラスチン前駆物質, 血液凝固11因子, 血液凝固第11因子, 第XI因子
Portuguese Fator XI de Coagulação, Antecedente Plasmático da Tromboplastina, Fator de Coagulação XI, Fator XI
Spanish antecedente de la tromboplastina plasmática, factor C antihemofílico, factor XI de la coagulación (sustancia), factor XI de la coagulación, Antecedente de la Tromboplastina Plasmica, Factor XI, Factor XI de Coagulación
German Faktor XI, Koagulationsfaktor XI, Plasma-Thromboplastin-Antecedent, Rosenthal-Faktor, Antihämophiler Plasma-Faktor C
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Factor XII (C0015525)

Definition (MSH) Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Definition (NCI) Coagulation factor XII ( 615 aa, ~68 kDa) is encoded by the human F12 gene. This protein is involved in blood coagulation and fibrinolysis.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005174
SnomedCT 70440005
LNC LP15979-5, LP21292-5
English Factor XII, Hageman Factor, coagulation factor XII, Blood-coagulation factor XII, Coagulation Factor XII, COAG FACTOR XII, Factor XII [Chemical/Ingredient], factor hageman, factor xii, hageman factor, Beta-Factor XIIa Part 1, Beta-Factor XIIa Part 2, EC 3.4.21.38, Coagulation Factor XIIa Heavy Chain, Coagulation Factor XIIa Light Chain, Coagulation factor XII, Hageman factor, Coagulation factor XII (substance)
French Facteur XII de la coagulation, Facteur XII de la coagulation sanguine, Facteur XII, Facteur Hageman, Facteur de Hageman
Swedish Faktor XII
Czech Hagemanův faktor, faktor XII
Finnish Hageman-tekijä
Russian KHAGEMANA FAKTOR, FAKTOR XII, KONTAKTNYI FAKTOR, KOAGULIATSII FAKTOR XII, КОАГУЛЯЦИИ ФАКТОР XII, КОНТАКТНЫЙ ФАКТОР, ФАКТОР XII, ХАГЕМАНА ФАКТОР
Italian Fattore Hageman, Fattore XII della coagulazione, Fattore XII della coagulazione del sangue, Fattore XII
Croatian KOAGULACIJSKI FAKTOR XII, KRV, KOAGULACIJA, FAKTOR XII, FAKTOR XII, HAGEMANOV FAKTOR
Polish Czynnik XII, Czynnik Hagemana
Japanese 血液凝固第XII因子, 血液凝固12因子, ハーゲマン因子, 接触因子, 血液凝固接触因子, 血液凝固第12因子, 第XII因子
Portuguese Fator XII de Coagulação, Fator de Coagulação XII, Fator de Hageman, Fator XII
Spanish factor Hageman, factor XII de la coagulación (sustancia), factor XII de la coagulación, Factor de Hageman, Factor XII, Factor XII de Coagulación
German Faktor XII, Hageman-Faktor, Koagulationsfaktor XII
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: factor XIII (C0015528)

Definition (MSH) A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.
Definition (CSP) fibrin-stabilizing plasma transglutaminase that is activated by thrombin and calcium to form factor XIIIa; important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.
Concepts Enzyme (T126) , Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH D005176
SnomedCT 319930009, 51161000
LNC LP21293-3, LP14703-0
English Factor XIII, Factor XIII Transamidase, Fibrin Stabilizing Factor, Fibrinase, Laki Lorand Factor, Laki-Lorand Factor, Stabilizing Factor, Fibrin, Transamidase, Factor XIII, fibrin stabilizing factor, Blood-coagulation factor XIII, Blood Coagulation Factor XIII, Coagulation Factor XIII, Factor XIII, Coagulation, XIII, Coagulation Factor, COAG FACTOR XIII, BLOOD COAG FACTOR XIII, Laki Lorand factor, FSF, Factor XIII [Chemical/Ingredient], laki lorand factor, factor xiii, coagulation factor XIII, factor XIII, Blood coagulation factor XIII, Coagulation factor XIII, Fibrin stabilizing factor, Laki-Lorand factor, Coagulation factor XIII (substance), Fibrin stabilising factor, fibrinase
French Facteur XIII de la coagulation sanguine, Facteur XIII de la coagulation, Facteur stabilisant de la fibrine, FSF (Facteur Stabilisant de la Fibrine), Fibrine-polymérase, Facteur de Laki-Lorand, Facteur Laki-Lorand, Facteur XIII, Fibrinase
Swedish Faktor XIII
Czech faktor XIII
Finnish Fibriiniä stabiloiva tekijä
Russian LAKI-LORAND FAKTOR, FIBRINAZA, FIBRINSTABILIZIRUIUSHCHII FAKTOR, KOAGULIATSII FAKTOR XIII, FAKTOR XIII, КОАГУЛЯЦИИ ФАКТОР XIII, ЛАКИ-ЛОРАНД ФАКТОР, ФАКТОР XIII, ФИБРИНАЗА, ФИБРИНСТАБИЛИЗИРУЮЩИЙ ФАКТОР
Japanese ラキ･ロランド因子, 血液凝固13因子, 血液凝固第XIII因子, フィブリン安定化因子, フィブリン安定因子, レーキーローランド因子, 血液凝固第13因子, XIII因子, ラキ-ロランド因子, 第XIII因子
Italian Fattore XIII della coagulazione del sangue, Fattore di Laki Lorand, Fattore XIII della coagulazione, Fattore stabilizzante la fibrina, Fattore di Laki-Lorand, Fattore XIII transamidasi, Fibrinasi, Fattore XIII
Croatian FAKTOR KOJI STABILIZIRA FIBRIN, FAKTOR XIII, KOAGULACIJSKI FAKTOR XIII, KRV, KOAGULACIJA, FAKTOR XIII, FIBRINAZA
Polish Transglutaminaza osoczowa, Czynnik XIII, Fibrynaza, Stabilizator fibryny, Czynnik stabilizujący włóknik, Czynnik Lakiego i Loranda
Portuguese Fator XIII de Coagulação, Fator de Coagulação XIII, Fator de Laki-Lorand, Fator Estabilizante de Fibrina, Fator XIII, Fator XIII Transamidase, Fibrinase
Spanish factor Laki - Lorand, factor XIII de la coagulación (sustancia), factor XIII de la coagulación, factor estabilizador de la fibrina, Factor Estabilizador de Fibrina, Factor Laki-Lorand, Factor XIII, Factor XIII Transamidasa, Fibrinasa, Factor XIII de Coagulación
German Faktor XIII-Transamidase, Faktor XIII, Fibrinase, Fibrinstabilisierender Faktor, Koagulationsfaktor XIII, Laki-Lorand-Faktor, Plasma-Protransglutaminase
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Fibrin (C0015982)

Definition (NCI) A glycosylated elastic protein produced by the cleavage of fibrinogen by the protease thrombin during blood coagulation.
Definition (MSH) A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Definition (CSP) insoluble protein that forms a network of fibers during blood clotting; derived from fibrinogen in the presence of thrombin.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D005337
SnomedCT 113361004
English Fibrin, Fibrins, Fibrin [Chemical/Ingredient], fibrin, fibrins, Fibrin (substance)
Swedish Fibrin
Czech fibrin
Finnish Fibriini
Russian FIBRIN, ANTITROMBIN I, АНТИТРОМБИН I, ФИБРИН
Croatian Not Translated[Fibrin]
Polish Fibryna, Włóknik
Spanish fibrina (sustancia), fibrina, Fibrina
French Fibrine
German Fibrin
Italian Fibrina
Portuguese Fibrina
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Hemostatic function (C0019116)

Definition (CHV) body function that stops bleeding by coagulating blood and constricting blood vessel
Definition (CHV) body function that stops bleeding by coagulating blood and constricting blood vessel
Definition (CHV) body function that stops bleeding by coagulating blood and constricting blood vessel
Definition (CHV) body function that stops bleeding by coagulating blood and constricting blood vessel
Definition (GO) The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. [ISBN:0198506732]
Definition (MSHCZE) Zástava krvácení. Podílí se na ní cévní stěna (vazokonstrikce a uvolnění některých látek), trombocyty a koagulace. Výsledkem těchto reakcí, které se vzájemně ovlivňují, je přechod krve z kapalného do tuhého stavu a vznik krevní sraženiny (koagula). Porucha h. může mít vážné důsledky (vykrvácení při poranění, operaci, spontánní krvácení). Naopak poruchy zpětnovazebných mechanismů se mohou podílet na zvýšené srážlivosti krve a vzniku trombózy. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI_FDA) The arrest of bleeding, either by the physiological properties of vasoconstriction and coagulation or by surgical means.
Definition (NCI) The arrest of bleeding, either by the natural processes of vasoconstriction and coagulation or by surgical means.
Definition (MSH) The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
Definition (CSP) process of arresting blood flow or bleeding, either physiologically by vasoconstriction and coagulation or by mechanical or surgical means.
Concepts Organ or Tissue Function (T042)
MSH D006487
SnomedCT 298115001, 74848003
English Hemostatic function, Hemostases, Hemostasis, hemostasis, haemostasis, hemostatic function, haemostatics, hemostases, hemostatic, haemostatic, stopping bleeding, HEMOSTASIS, Haemostasis, Haemostatic function, Hemostatic function (observable entity), Hemostasis, NOS, Hemostatic function, NOS, Haemostasis, NOS, Haemostatic function, NOS, Hemostatic function (function)
Swedish Blodstillning
Czech hemostáza
Finnish Hemostaasi
Russian GEMOSTAZ, ГЕМОСТАЗ
Croatian HEMOSTAZA
Polish Hemostaza
Norwegian Hemostase
Spanish Hemostasia, función hemostática (entidad observable), función hemostática (función), función hemostática, hemostasia, Hemostasis
French Hémostase
German Blutstillung, Hämostase
Italian Emostasi
Dutch Hemostase
Portuguese Hemostasia
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Prothrombin (C0033706)

Definition (NCI) Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen.
Definition (MSH) A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Definition (CSP) plasma protein precursor of thrombin, converted to thrombin by a prothrombin activator complex; deficiency of prothrombin leads to hypoprothrombinemia.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D011516
SnomedCT 7348004
LNC LP16010-8, LP21283-4
English Differentiation Reversal Factor, Factor II, Factor, Differentiation Reversal, Prothrombin, Blood-coagulation factor II, Blood Coagulation Factor II, Coagulation Factor II, Factor II, Coagulation, II, Coagulation Factor, COAG FACTOR II, BLOOD COAG FACTOR II, EC 3.4.21.5, Prothrombin [Chemical/Ingredient], prothrombin, prothrombin factor ii, factor ii prothrombin, factor ii (prothrombin), coagulation factor II, Coagulation factor II, Coagulation factor II (substance)
French Facteur II de la coagulation, Facteur II, Facteur II de la coagulation sanguine, Prothrombine
Swedish Protrombin
Czech faktor II, prothrombin
Finnish Protrombiini
Russian FAKTOR II, PROTROMBIN, ПРОТРОМБИН, ФАКТОР II
Japanese 血液凝固第II因子, プロトロンビン, 血液凝固第2因子, プロスロンビン
Polish Protrombina, Czynnik krzepnięcia II
Croatian PROTROMBIN
Norwegian Blodkoagulasjonsfaktor II, Faktor II, Differentiation reversal factor, Protrombin, Koagulasjonsfaktor II
Portuguese Fator II de Coagulação, Fator de Coagulação II, Fator II, Protrombina
Spanish factor II de la coagulación de la sangre, factor II de la coagulación, protrombina (sustancia), protrombina, Protrombina, Factor II, Factor II de Coagulación
German Faktor II, Koagulationsfaktor II, Prothrombin
Italian Protrombina
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Thrombin (C0040018)

Definition (MSH) An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D013917
SnomedCT 48421007, 36176003, 415715002
HL7 THROM
LNC LP21102-6
English Thrombase, Thrombin, fibrinogenase, thrombase, Thrombin agent, thrombin (medication), Thrombin [Chemical/Ingredient], THROMBIN, Thrombin agent (substance), thrombin, Fibrinogenase, Thrombin (substance), Thrombin preparation (substance), Thrombin preparation, Thrombin (product)
Swedish Trombin
Czech thrombin
Finnish Trombiini
Russian TROMBIN, FIBRINOGENAZA, TROMBAZA, ТРОМБАЗА, ТРОМБИН, ФИБРИНОГЕНАЗА
Spanish Trombina (producto), trombina (producto), Trombina, preparado de trombina (sustancia), preparado de trombina, fibrinogenasa, trombina (sustancia), trombina, Trombasa
French Thrombase, Fibrinogenase, Thrombine
Croatian TROMBIN
Polish Trombina
Japanese トロンバース, トロンビン
German Thrombase, Thrombin
Italian Trombina
Portuguese Trombase, Trombina
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Thromboplastin (C0040048)

Definition (SCTSPA) Factor tisular, receptor de alta afinidad y cofactor de la proteasa de serina plasmática VII/VIIa
Definition (SNOMEDCT_US) Tissue factor, the high-affinity receptor and cofactor for the plasma serine protease VII/VIIa
Definition (SNOMEDCT_US) Tissue factor, the high-affinity receptor and cofactor for the plasma serine protease VII/VIIa
Definition (NCI) Human coagulation factor-III protein (295 aa, 33 kDa precursor) is encoded by the human coagulation factor III (thromboplastin, tissue factor) (F3) gene. The factor is a glycoprotein/phospholipid, which functions as a potent high-affinity transmembrane receptor/cofactor for coagulation factor VII. The protein also plays an important role in blood coagulation.
Definition (MSH) Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
Definition (CSP) coagulation factor important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation; derived from several sources in the body including brain and lungs.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D013925
SnomedCT 387124009, 22634000, 50857004, 319856001, 5172001, 65265006, 123340007
English Activity, Glomerular Procoagulant, Coagulin, Factor III, Glomerular Procoagulant Activity, Procoagulant Activity, Glomerular, Procoagulant, Tissue Factor, Prothrombinase, Thromboplastin, Thromboplastin, Tissue, Tissue Factor, Tissue Factor Procoagulant, Tissue Thromboplastin, Urothromboplastin, Blood-coagulation factor III, Blood Coagulation Factor III, Coagulation Factor III, Factor III, Coagulation, tissue factor, prothrombinase, COAG FACTOR III, BLOOD COAG FACTOR III, GLOMERULAR PROCOAG ACTIVITY, ANTIGENS CD 142, TISSUE FACTOR PROCOAG, CD 142 ANTIGENS, F3 Protein, Tissue factor, Tissue thromboplastin, Coagulation factor III, Antigens, CD142, CD142 Antigens, Thromboplastin [Chemical/Ingredient], factors tissue, thromboplastin, tissue thromboplastin, factor iii, coagulation factor III, Thromboplastin preparation (product), Tissue factor (substance), Thromboplastin preparation, Thromboplastin (product), Thromboplastin (substance), Thromboplastin product, Thrombokinase, Thromboplastin, NOS, Thromboplastin preparation (substance), F3, CD142 Antigen
French Facteur III de la coagulation, Facteur III de la coagulation sanguine, Facteur III, Coaguline, Antigène CD142, Facteur tissulaire, Thromboplastine tissulaire, Facteur tissulaire procoagulant, CD142, Prothrombinase, Thromboplastine
Swedish Tromboplastin
Czech thromboplastin, faktor III
Spanish preparado con tromboplastina (sustancia), tromboplastina tisular, tromboplastina (sustancia), factor III de la coagulación, tromboplastina de los tejidos, preparado con tromboplastina (producto), factor III de la coagulación (sustancia), factor tisular, preparado con tromboplastina, preparado de tromboplastina (producto), preparado de tromboplastina (sustancia), preparado de tromboplastina, tromboplastina (producto), tromboplastina, Tromboplastina, Factor del Tejido, Factor III, Tromboplastina de Tejido, Antígenos CD142, Factor III de Coagulación
Finnish Tromboplastiini
Russian ANTIGENY, CD142, TKANEVOI FAKTOR, TROMBOPLASTIN, KOAGULIATSII FAKTOR III, TROMBOPLASTIN TKANEVOI, CD142 ANTIGENY, FAKTOR III, CD142 АНТИГЕНЫ, АНТИГЕНЫ, CD142, КОАГУЛЯЦИИ ФАКТОР III, ТКАНЕВОЙ ФАКТОР, ТРОМБОПЛАСТИН, ТРОМБОПЛАСТИН ТКАНЕВОЙ, ФАКТОР III
German ANTIGENE CD 142, CD 142 ANTIGENE, Faktor III, Gewebefaktor, Gewebethromboplastin, Koagulationsfaktor III, Prothrombin-Aktivator, Thromboplastin, Antigene, CD142-, CD142-Antigene, Prothrombinase
Polish Czynnik III, Czynnik tkankowy, Tromboplastyna
Japanese 血液凝固第III因子, CD142抗原, トロンボプラスチン, 組織トロンボプラスチン, 組織因子, 血液凝固第3因子
Portuguese Fator III de Coagulação, Antígenos CD142, Fator de Coagulação III, Fator III, Fator Tecidual, Tromboplastina, Tromboplastina Tecidual
Italian Tromboplastina
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Clot formation (C1821761)

Concepts Laboratory Procedure (T059)
LNC LP69275-3, MTHU028148
English Clot formation
Derived from the NIH UMLS (Unified Medical Language System)

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