II. Indication
-
Bleeding Disorder
- Replaced by von specific tests (Willebrand Factor Activity, Von Willebrand Factor Antigen, Factor VIII Level)
- Historical indications
- Replaced Bleeding Time to assess Platelet function
- Personal or Family History of easy Bruising or bleeding
- Epistaxis
- Menorrhagia
- Post-operative bleeding
III. Protocol: Sample
- Citrate anticoagulated whole blood
IV. Mechanism
- Rapid quantitation of Platelet function for Hemostasis
- Blood passed through high shear flow system
- System measures time to occlude membrane
- Blood is tested with two membranes
- Collagen/Epinephrine (CEPI) membrane
- Collagen/Adenosine Diphosphate (CADP) membrane specific for Aspirin
V. Interpretation: Normal
- CEPI closure <175
VI. Causes: Abnormal (prolonged closure time)
- Von Willebrand's Disease
- Glanzmann's Thrombasthenia
- Thrombasthenia
- Thrombocytopenia with Platelet Count <100,000/mm3
- Anemia with Hematocrit <35%
- Aspirin (will prolong only the CEPI membrane time)
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Related Studies
| Definition (NCI) | The determination of the collagen closure time, as a surrogate of platelet function, present in a sample. |
| Definition (NCI_CDISC) | A measurement of the platelet function closure time in a biological specimen. |
| Concepts | Laboratory Procedure (T059) |
| English | Platelet Function Closure Time, Platelet Function Closure Time Measurement, PFCT |
