Leukocyte Morphology on Peripheral Smear

Aka: Leukocyte Morphology on Peripheral Smear, Leukocyte Morphology, White blood Cell morphology, Hypersegmented Neutrophil, Bilobed Neutrophil, Atypical lymphocyte, Toxic granulation, Lymphoblast, Plasmablast, Myeloblast, Promyelocyte, Myelocyte

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II. Background

  1. Variants below as seen on Peripheral Smear

III. Toxic granulation of Neutrophils and Metamyelocytes

  1. Bacterial Infections

IV. Atypical lymphocytes

  1. Viral Infections

V. Giant cytoplasmic granules

  1. Chediak-Higashi Syndrome

VI. Bilobed Neutrophils

  1. Pelger-Huet anomaly

VII. Hypersegmented Neutrophils

  1. Pernicious Anemia (Vitamin B12 Deficiency)
  2. Folate Deficiency
  3. Myeloproliferative disease

VIII. Myeloblasts, Promyelocytes, Myelocytes

  1. Acute Myeloblastic Leukemia
  2. Acute promyelocytic Leukemia
  3. Chronic myelocytic Leukemia
  4. Myelofibrosis
  5. Polycythemia Vera

IX. Large Granular Lymphocytes

  1. T-gamma lymphoproliferative disease
    1. Natural Killer Cells

X. Lymphoblasts

  1. Acute Lymphoblastic Leukemia
  2. Prolymphocytic Leukemia
  3. Malignant Lymphoma
  4. Chronic Lymphocytic Leukemia
  5. Infectious Mononucleosis

XI. Plasmablasts

  1. Multiple Myeloma

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