II. Background
- Variants below as seen on Peripheral Smear
III. Causes: Toxic granulation of Neutrophils and Metamyelocytes
IV. Causes: Atypical lymphocytes
- Characteristics
- Larger Lymphocytes with more cytoplasm
- Nuclei contain nucleoli
- Causes: Viral Infections
V. Causes: Giant cytoplasmic granules
VI. Causes: Bilobed Neutrophils
- Pelger-Huet anomaly
VII. Causes: Hypersegmented Neutrophils
- Pernicious Anemia (Vitamin B12 Deficiency)
- Folate Deficiency
- Myeloproliferative disease
VIII. Causes: Myeloblasts, Promyelocytes, Myelocytes
- Acute Myeloblastic Leukemia
- Acute promyelocytic Leukemia
- Chronic myelocytic Leukemia
- Myelofibrosis
- Polycythemia Vera
IX. Causes: Large Granular Lymphocytes
- T-gamma lymphoproliferative disease
X. Causes: Lymphoblasts
- Acute Lymphoblastic Leukemia
- Prolymphocytic Leukemia
- Malignant Lymphoma
- Chronic Lymphocytic Leukemia
- Infectious Mononucleosis
XI. Plasmablasts
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Related Studies
Definition (NCI) | A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes. |
Definition (MSH) | The cells in the granulocytic series that are derived from myeloblasts and that are the earliest cells of the myelocyte stage. |
Concepts | Cell (T025) |
MSH | D042381 |
SnomedCT | 43446009 |
LNC | LP15084-4, MTHU012804 |
French | Promyélocyte, Progranulocytes, Promyélocytes |
English | Promyelocytes, promyelocytes, promyelocyte, Premyelocytes, Premyelocyte, Progranulocytes, Promyelocyte, Progranulocyte, Promyelocyte (cell), Progranulocyte, NOS, Promyelocyte, NOS |
Czech | promyelocyty |
Portuguese | Promielócitos |
Spanish | Promielocitos, progranulocito, promielocito (célula), promielocito |
German | Progranulozyten, Promyelozyten |
Norwegian | Premyelocytter, Progranulocytter, Promyelocytter |
Dutch | Promyelocyten |
Ontology: Atypical lymphocyte (C0221277)
Concepts | Cell (T025) |
SnomedCT | 52641009, 270921005 |
LNC | LP19572-4, MTHU013617 |
English | Atypical lymphocyte, LYMPHOCYTES ATYPICAL, Reactive lymphocyte, Lymphocytes atypical, atypical lymphocyte, atypical lymphocytes, reactive lymphocyte, lymphocytes reactive, lymphocyte atypical, Atypical lymphocytes (cell), Lymphocytes.abnormal, Atypical Lymphocyte, Atypical lymphocytes, Atypical lymphocyte (morphologic abnormality), Atypical lymphocyte (cell), Atypical lymphocytes (morphologic abnormality), Abnormal Lymphocyte, Reactive Lymphocyte |
Dutch | atypische lymfocyten, lymfocyten atypisch |
French | Lymphocytes atypiques, LYMPHOCYTES ATYPIQUES |
German | atypische Lymphozyten, Lymphozyten atypisch, LYMPHOZYTEN ATYPISCH |
Italian | Linfociti atipici |
Portuguese | Linfócitos atípicos, LINFOCITOS ATIPICOS |
Spanish | Linfocitos atípicos, LINFOCITOS ATIPICOS, linfocito atípico (anomalía morfológica), linfocito atípico, linfocito reactivo (anomalía morfológica), linfocito reactivo |
Japanese | 異型リンパ球, イケイリンパキュウ |
Czech | Atypické lymfocyty |
Hungarian | Atípusos limfociták, Limfociták atípusos |
Ontology: lymphoblast (C0229613)
Definition (NCI_NCI-GLOSS) | A lymphocyte that has gotten larger after being stimulated by an antigen. Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte. |
Definition (NCI) | An immature lymphocyte that has enlarged in response to antigenic stimulation. |
Definition (CSP) | a morphologically immature lymphocyte, once thought to represent an early stage in lymphocyte development but now known to be an activated lymphocyte that has been transformed in response to antigenic stimulation. |
Concepts | Cell (T025) |
SnomedCT | 15433008 |
LNC | LP31546-2, LP172715-7, MTHU046401, MTHU015669 |
English | lymphoblasts, Lymphoblasts, lymphoblastic, Lymphoblast, Lymphocytoblast, Lymphoblast (cell), lymphoblast |
Spanish | linfoblasto (célula), linfoblasto, linfocitoblasto |
Ontology: myeloblast (C0229633)
Definition (NCI) | An immature cell that represents the first stage in the granulocytic series of hematopoiesis. It is found in bone marrow and differentiates into a promyelocyte. Its nucleus is composed of very fine, evenly distributed chromatin with 2-5 nucleoli. The cytoplasm is basophilic and non-granular. |
Definition (NCI_NCI-GLOSS) | Refers to myeloblasts (a type of immature cell that forms in the bone marrow). |
Concepts | Cell (T025) |
MSH | D042381 |
SnomedCT | 15622002 |
LNC | LP15076-0, MTHU014308 |
French | Myéloblaste, Myéloblastes |
Czech | myeloblasty |
Portuguese | Mieloblastos |
Spanish | Mieloblastos, mieloblasto (célula), mieloblasto |
German | Myeloblasten |
English | myeloblasts, myeloblastic, Myeloblast, Myeloblast (cell), myeloblast, Myeloblasts |
Norwegian | Myeloblast, Myeloblaster |
Dutch | Myeloblasten |
Ontology: Plasmablast (cell) (C0229657)
Concepts | Cell (T025) |
SnomedCT | 2579009 |
English | Plasmablast (cell), Plasmablast |
Spanish | plasmoblasto (célula), plasmoblasto |
Ontology: Myelocytes (C0369715)
Definition (NCI) | A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin. |
Definition (CSP) | precursor in the granulocytic series; in this stage, differentiation into specific cytoplasmic granules has begun. |
Concepts | Cell (T025) |
MSH | D042381 |
SnomedCT | 165545002, 127915008 |
LNC | LP15077-8, MTHU014310 |
French | Myélocyte, Myélocytes |
English | Myelocytes, myelocyte, myelocytes, Myelocyte, Myelocyte (cell) |
German | Myelozyten |
Norwegian | Myelocytter |
Spanish | mielocito (célula), mielocito |
Ontology: Hypersegmented neutrophil (C0483202)
Concepts | Cell or Molecular Dysfunction (T049) |
SnomedCT | 127564008 |
LNC | LP17593-2, MTHU013775, LA11188-2 |
English | hypersegmented neutrophil, hypersegmented neutrophils, Hypersegmented neutrophils, Neutrophils.hypersegmented, Hypersegmented neutrophil (morphologic abnormality), Hypersegmented neutrophil, Hypersegmented neutrophil (cell) |
Spanish | neutrófilo hipersegmentado (anomalía morfológica), neutrófilo hipersegmentado (célula), neutrófilo hipersegmentado |