C-Reactive Protein as Cardiac Risk Factor

Aka: C-Reactive Protein as Cardiac Risk Factor, CRP as Cardiac Risk Marker, High-Sensitivity CRP in Evaluating Cardiac Risk, hs-CRP for CAD Evaluation

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II. Indications

  1. Not recommended for routine screening currently
    1. Not specific for Coronary Artery Disease
    2. Large day to day variablity in values
    3. No clear strategy for elevated values
    4. Kushner (2002) Arch Intern Med 162:867-9 [PubMed]
    5. Ridker (2002) N Engl J Med 347:1557-65 [PubMed]
  2. High-Sensitivity CRP may be used in high-risk patient
    1. hs-CRP >3 mg/L predicts more ischemic episodes
    2. Elevated hs-CRP may dictate more intense therapy
    3. Rosenson (2003) Am J Cardiol 92:10i-18i [PubMed]

III. Efficacy: Increased C-RP as Cardiac Risk marker

  1. Comparatively weak predictor of heart disease
  2. Odds Ratio C-RP: 1.45
  3. Odds Ratio Increased SBP: 1.50
  4. Odds ratio Tobacco Abuse: 1.87
  5. Odds Ratio Increased Total Cholesterol: 2.35
  6. Danesh (2004) N Engl J Med 350:1387-97 [PubMed]

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